3 ms·
Maybe this is pessimistic but I think a lot of the reason for the switch from MAOIs to SSRIs comes from people not wanting to gain weight. SSRIs tend not to ha
by ghostbrainalpha 7y ago
Maybe this is pessimistic but I think a lot of the reason for the switch from MAOIs to SSRIs comes from people not wanting to gain weight.
SSRIs tend not to have that side effect and less side effects in general, even though they are definitely less effective.
- InitialLastName 7y agoFrom my experience with loved ones' struggles with medicating mental illness, much of the difficulty is in finding a treatment regimen that's both effective enough to function normally and minimizes side effects. If SSRI's work well enough for some chunk of the depressed population and have fewer side effects than the alternatives, why would "lets try that first" be a pessimistic outcome?
- cookiecaper 7y agoBecause "fewer side effects" is such a massive overgeneralization that it's meaningless. Side effects are different for each drug and there's no reason to assume the patient would prefer the side effects of an ineffective SSRI to an effective MAOI right out of the gate. Additionally, each doctor wants you to try the less-effective drug for months at a time, each revision in the medication requires an expensive and time-consuming follow-up appointment at which point the doctor won't remember anything about you anyway, and SSRIs have their own non-trivial side effect profiles and withdrawal symptoms. It's just not as simple as -- or at least shouldn't be as simple as -- "oh, this one has fewer side effects!" It's especially bad in the case of SSRIs, because to switch from an SSRI to an MAOI or vice-versa, you have to "wash out" (that is, go unmedicated) for at least two weeks, during which time the person is unlikely to be functional regardless of their natural chemistry because they'll be withdrawing from the old medication.