3 ms·
PD-(L)1 inhibitors are a special class though and help the immune system in becoming sensitive to tumor cells and start killing them around the body. Other MAbs
by teekert 7y ago
PD-(L)1 inhibitors are a special class though and help the immune system in becoming sensitive to tumor cells and start killing them around the body. Other MAbs like Bevacizumab (an angiogenesis inhibitor, prevents formation of new blood vessels) or Herceptin (Trastuzumab, targets the HER2 membrane protein often over-expressed in certain types of breast cancer) have been on the market for much longer and fall under so called "targeted treatments". The targeted drugs hardly ever lead to a cure, whereas the new immune drugs may even cure people from metastasized cancer (in 30 to 60% of cases in some tumor types). Be aware that the side effects of the new immune drugs may also be severe and mimic auto-immune disease-like symptoms, essentially you are forcing your immune system into higher gear (higher sensitivity, less specificity).
[0] https://en.wikipedia.org/wiki/Bevacizumab https://en.wikipedia.org/wiki/Bevacizumab