> Fat accumulation or loss is simple physics. No, it isn't. The biochemistry controlling nutrient uptake or release by different tissues is incredibly complex

> Fat accumulation or loss is simple physics. No, it isn't. The biochemistry controlling nutrient uptake or release by different tissues is incredibly complex and nowhere near fully understood, which is part of the reason that studies like this one are interesting. We don't really know how any given calorie surplus or deficit maps to subcutaneous fat vs. visceral fat vs. thermogenesis vs. muscle vs. fatty liver. We don't really know why some people develop T2D at a normal weight, some people only develop it if they're obese, and some people never develop it despite being morbidly obese. Pretending that this is a simple and solved problem doesn't really help anybody except authors of diet books.