Agreed. Imo, psilocybin won't just magically fix a chemical imbalance in your head. But it can open you up (for the duration of its effect) to some thoughts and

Agreed. Imo, psilocybin won't just magically fix a chemical imbalance in your head. But it can open you up (for the duration of its effect) to some thoughts and ideas that could help you resolve your internal issues causing you depression, and those thoughts and realizations are what can help with getting rid of depression, as those realizations can stay with you even after the trip is over. Which is somewhat similar to what i have read about the ketamine therapy, which essentially just makes certain areas of your brain more neuroplastic for a short duration, helping you get out of your routine thought patterns and help create new neural pathways and reshape the existing ones easier. Note: I am not a brain researcher myself at all, so what I said could totally be just some pseudoscientific bs, but that's what I got after reading a bunch on both of the topic in a lot of places, including other HN threads. If you want to correct some misunderstandings in my post, please feel free to reply. I will be very happy to correct my misunderstandings.