I like the work that Cortexyme is doing [1] here: But in 2019, evidence pointed the finger elsewhere: at Porphyromonas gingivalis, a type of bacteria invol

I like the work that Cortexyme is doing [1] here: But in 2019, evidence pointed the finger elsewhere: at Porphyromonas gingivalis, a type of bacteria involved in gum disease. Research ... suggests that beta-amyloid is a symptom, not a cause of the condition. Instead, it may be the toxins released by P. gingivalis, called gingipains, that result in the brain damage that brings on the disease. Cortexyme is currently conducting a clinical trial to test an experimental drug that block gingipains. Their hypothesis coincidentally also explains why Alzheimer prevalence differs among ApoE genotypes. (I posted the story earlier today [2], but it didn't end up on the front page.) [1] https://www.newscientist.com/article/mg24432613-800-im-testing-an-experimental-drug-to-see-if-it-halts-alzheimers/ https://www.newscientist.com/article/mg24432613-800-im-testi... [2] https://news.ycombinator.com/item?id=21917192 https://news.ycombinator.com/item?id=21917192