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Polygenic scores for IQ are correlated with other traits that are less desirable (schizophrenia for example). I think the lift in IQ you get from embryo select

Polygenic scores for IQ are correlated with other traits that are less desirable (schizophrenia for example). I think the lift in IQ you get from embryo selection is counteracted by a lot of other (negative) factors. It is also unclear to what degree epigenetic inheritance plays in IQ. My opinion is the 8-10 IQ point boost is less than variance from unknown factors relating to doing IVF versus natural birth. In other words I would still go with natural birth (which has been time tested by evolution)

ZhuanXia 7y ago
>Polygenic scores for IQ are correlated with other traits that are less desirable (schizophrenia for example). Nope. IQ is negatively correlated with most mental illness. It is certainly not positively correlated with schizophrenia: https://www.gwern.net/iq https://www.gwern.net/iq
- mlyle 7y ago
  This has positively nothing to do with what he said.
  - ZhuanXia 7y ago
    Read it again. It clearly does.
    - mlyle 7y ago
      I read it again, it clearly doesn't. ;) As it turns out, we have multiple contradictory findings about whether high IQ is positively or negatively correlated with mental illness. But even if you believe there's a negative correlation, it doesn't mean that many predictive SNPs can't predict both. E.g. cloud cover is predictive both for rainfall and heavy snow. However, heavy snow is negatively correlated with rainfall. The latter doesn't negate the former.
- stanfordkid 7y ago
  This is certainly not something that can be answered with a simple Yes or No. I am by no means saying that the underlying traits are casually related — only that metrics which predict one may also predict the other. The human brain is a complex system and IQ itself is a very simplistic way to characterize it. Think of it this way: imagine IQ is like electricity powering a city. Different city configurations have very different power and load requirements. You might find that, in general, cities with more power function better. But perhaps the well functioning cities also had better transmission infrastructure. If you applied the rule of “more power is better” to a city without that infrastructure it would blow fuses everywhere and cause chaos. With this example aside, In fact the science does say that there is a relationship: https://www.nature.com/articles/s41380-018-0332-x?WT.feed_name=subjects_neuroscience https://www.nature.com/articles/s41380-018-0332-x?WT.feed_na...

ZhuanXia 7y ago

>Polygenic scores for IQ are correlated with other traits that are less desirable (schizophrenia for example). Nope. IQ is negatively correlated with most mental illness. It is certainly not positively correlated with schizophrenia: https://www.gwern.net/iq https://www.gwern.net/iq

mlyle 7y ago
This has positively nothing to do with what he said.
- ZhuanXia 7y ago
  Read it again. It clearly does.
  - mlyle 7y ago
    I read it again, it clearly doesn't. ;) As it turns out, we have multiple contradictory findings about whether high IQ is positively or negatively correlated with mental illness. But even if you believe there's a negative correlation, it doesn't mean that many predictive SNPs can't predict both. E.g. cloud cover is predictive both for rainfall and heavy snow. However, heavy snow is negatively correlated with rainfall. The latter doesn't negate the former.
stanfordkid 7y ago
This is certainly not something that can be answered with a simple Yes or No. I am by no means saying that the underlying traits are casually related — only that metrics which predict one may also predict the other. The human brain is a complex system and IQ itself is a very simplistic way to characterize it. Think of it this way: imagine IQ is like electricity powering a city. Different city configurations have very different power and load requirements. You might find that, in general, cities with more power function better. But perhaps the well functioning cities also had better transmission infrastructure. If you applied the rule of “more power is better” to a city without that infrastructure it would blow fuses everywhere and cause chaos. With this example aside, In fact the science does say that there is a relationship: https://www.nature.com/articles/s41380-018-0332-x?WT.feed_name=subjects_neuroscience https://www.nature.com/articles/s41380-018-0332-x?WT.feed_na...