3 ms·
Moderate to heavy doses of psilocybin at quarterly intervals can eliminate migranes and cluster headaches.
by jobaoana 7y ago
Moderate to heavy doses of psilocybin at quarterly intervals can eliminate migranes and cluster headaches.
- AstralStorm 7y agoThey are somewhat chemically similar to triptans, and consequently usually do not work for migraines resistant to triptans. But then, there's a lot of variance there. But yes, they do sometimes work and when they do it's relatively long term compared to regular triptan use. And allegedly they're much more potent, especially when it comes to aborting migraines. Some non-hallucinogenic chemical variants are being also researched, both of psilocybin and LSD. LSA has also shown effectiveness sometimes. At least 3 phase 1/2B-style RCTs of hallucinogens are under way. (Finding working doses, schedules, cataloguing side effects.) Expect results of one for psilocybin mid 2020. There's also long running RCT of LSD, finishing in 2023. I think both of these are for cluster headaches rather than migraines, but close enough. Pilot trials have been done a long time ago by MAPS, with success. Now it's time for bigger science. The link is also somewhat interestingly tenuous with ECT and seizures. (In that migraines and seizures rarely coexist, but share symptoms in some cases.)