4 ms·

> Nothing with any scientific rigor. Of course I, like I'm sure everyone else, believe I have a decent "placebo detector" and to that end CBD isn't behaving lik

> Nothing with any scientific rigor. Of course I, like I'm sure everyone else, believe I have a decent "placebo detector" and to that end CBD isn't behaving like a placebo for me. This statement invalidates everything that follows after. Do multiple blind trials with a control substance at varying threshold doses, then you can say whether these "feelings" are from the drug itself. Placebo creates a very real, measurable physiological effect, so relying on your subjective experience is more than "scientifically unrigorous", it's actually flawed reasoning. And citing a lack of evidence doesn't mean you can suddenly use your own anecdotal data as evidence.

nefitty 7y ago
I understand where you're coming from, but do you expect all people to discount their own experiences because they don't meet some threshold of validity? Humans don't live daily life like that. I think there's value in anecdotal data, especially when presented with the appropriate caveats. Otherwise, is my entire life a sham unless it is backed up by double blind trials?
- soulofmischief 7y ago
  It's not about the threshold of validity. It's about the threshold dose used, whose psychoactive effects are generally placed at higher doses. There is no value in anecdotal data when this is something that can be properly measured, especially when it has to do with medical science and people's lives are involved. OP is making bogus, unsubstantiated claims and does not need to be defended.
perl4ever 7y ago
Anybody who believes in the placebo effect is not to be taken seriously. If you think you can measure the placebo effect, what did you use as your control in your double blind study? That is, your control group which did not get a placebo, but believed they were getting a placebo, how exactly did you manage that?
- soulofmischief 7y ago
  > Anybody who believes in the placebo effect is not to be taken seriously. Uhhhhhh no, sorry. Anybody who believes placebo is not a real physiological phenomenon is not to be taken seriously, because they have not done their basic homework. > what did you use as your control in your double blind study? I didn't do one, because I am not here claiming that 1mg of CBD is enough to feel. The responsibility is on OP, not me. But to answer a hypothetical, what would I use as my control? The same solution I would be placing the CBD in, sans the CBD. It's not hard. https://en.wikipedia.org/wiki/Placebo#Mechanisms https://en.wikipedia.org/wiki/Placebo#Mechanisms
  - perl4ever 7y ago
    Please don't take me so literally. I understand you didn't do a study on the placebo effect or anything else. I'm asking something that I wish you would seriously consider. If you only believe in things that are proven through double-blind studies, and you believe the placebo effect objectively exists, then it must be possible to do a double-blind study proving the placebo effect exists. Have you read about such a thing, or can you imagine such a thing? Do you, if you look again at my previous comment, see any possible logical problem? I'm questioning your belief structure - I have no particular opinion on CBD, nor do I think controlled studies are useless.
Smithalicious 7y ago
Not all text on the internet is meant to be a scientific paper. It's totally valid to claim that something works for you without having to do "multiple blind trials with a control substance at varying threshold dose".
- soulofmischief 7y ago
  Not when we're discussing the effects of threshold doses vs. placebo. Placebo reactions can easily mimic threshold effects.

nefitty 7y ago

I understand where you're coming from, but do you expect all people to discount their own experiences because they don't meet some threshold of validity? Humans don't live daily life like that. I think there's value in anecdotal data, especially when presented with the appropriate caveats. Otherwise, is my entire life a sham unless it is backed up by double blind trials?

soulofmischief 7y ago
It's not about the threshold of validity. It's about the threshold dose used, whose psychoactive effects are generally placed at higher doses. There is no value in anecdotal data when this is something that can be properly measured, especially when it has to do with medical science and people's lives are involved. OP is making bogus, unsubstantiated claims and does not need to be defended.

perl4ever 7y ago

Anybody who believes in the placebo effect is not to be taken seriously. If you think you can measure the placebo effect, what did you use as your control in your double blind study? That is, your control group which did not get a placebo, but believed they were getting a placebo, how exactly did you manage that?

soulofmischief 7y ago
> Anybody who believes in the placebo effect is not to be taken seriously. Uhhhhhh no, sorry. Anybody who believes placebo is not a real physiological phenomenon is not to be taken seriously, because they have not done their basic homework. > what did you use as your control in your double blind study? I didn't do one, because I am not here claiming that 1mg of CBD is enough to feel. The responsibility is on OP, not me. But to answer a hypothetical, what would I use as my control? The same solution I would be placing the CBD in, sans the CBD. It's not hard. https://en.wikipedia.org/wiki/Placebo#Mechanisms https://en.wikipedia.org/wiki/Placebo#Mechanisms
- perl4ever 7y ago
  Please don't take me so literally. I understand you didn't do a study on the placebo effect or anything else. I'm asking something that I wish you would seriously consider. If you only believe in things that are proven through double-blind studies, and you believe the placebo effect objectively exists, then it must be possible to do a double-blind study proving the placebo effect exists. Have you read about such a thing, or can you imagine such a thing? Do you, if you look again at my previous comment, see any possible logical problem? I'm questioning your belief structure - I have no particular opinion on CBD, nor do I think controlled studies are useless.

Smithalicious 7y ago

Not all text on the internet is meant to be a scientific paper. It's totally valid to claim that something works for you without having to do "multiple blind trials with a control substance at varying threshold dose".

soulofmischief 7y ago
Not when we're discussing the effects of threshold doses vs. placebo. Placebo reactions can easily mimic threshold effects.