Fwiw, Scott Alexander wrote a couple great articles about depression in 2017: https://slatestarcodex.com/2017/09/12/toward-a-predictive-theory-of-depression/ h

Fwiw, Scott Alexander wrote a couple great articles about depression in 2017: https://slatestarcodex.com/2017/09/12/toward-a-predictive-theory-of-depression/ https://slatestarcodex.com/2017/09/12/toward-a-predictive-th... https://slatestarcodex.com/2017/06/13/what-is-depression-anyway-the-synapse-hypothesis/ https://slatestarcodex.com/2017/06/13/what-is-depression-any... The first tries to fit it into a predictive processing framework, the second rounds up a variety of findings, including correlation with inflammation and treatment with ketamine.