3 ms·

I've never heard of this before. What dose and what schedule is that dose on? Is it combined with any other treatments? How has it helped you? Do you have any s

I've never heard of this before. What dose and what schedule is that dose on? Is it combined with any other treatments? How has it helped you? Do you have any sources describing this mode of treatment? Any evidence of said inflammation or its subsequent reduction after treatment? Also, recreational use != party druggies. I put recreational in quotes because authorities etc. see no difference between self-medication and party time. Based on what you said, you could go get ketamine from a street dealer and continue the same dosage/schedule 'recreationally'. I'm not saying all recreational drug use is theraputic. I'm saying the difference between 'street drug' and 'medicine' is decided mostly on politics and the profitability profile of the substance rather than its therapeutic efficacy. Also see: marijuana.

WalterSear 7y ago
60mg every 3 days. I don't believe it's a common treatment modality - though my doctor has some other patients on it. The primary sensation I experience on an ongoing basis is the the elimination of the sensation of abstract physical pain that I experience with negative thoughts and mood. The process is not inherently anti-inflammatory: while high dose IV ketamine are used to treat inflammatory diseases, as I understand it, the dose I'm taking doesn't directly affect inflammation, but works by modulating glutamate signaling. The relationship between inflammation and mood isn't yet clear to science, but we know that it is likely involved in many cases of treatment resistant depression. Third hand, I know of people who are taking black market ketamine to treat depression, though I don't know what schedule they are following. There's a definite 'cliff' at the third day, as the ketamine wears off.
- missosoup 7y ago
  Rather unique and interesting case. I'm glad you found something that works for you.
- w1nst0nsm1th 7y ago
  60mg every 3 days. That's was the protocol I followed with auto-prescribed ketamine. Then I wanted to try every NMDA antagonists existing other than ketamine, like memantine, used as alzheimer treatment, but also ephenidine, diphenidine, methoxphenidine and later MXPr, all present in research chemical scene. Then I heard about dextromethorphan (DXM) on a drug forum about anecdotical experience on its potential as antidepressive and even read a scientific paper about it. It is used as composent in cough syrop worldwide and, according to country laws, available without legal restriction or not, mainly because it is reputed for its potential of abuse for its dissociative effect. In Belgium, it is supposed to be unrestricted for possession and use and so I bought 100gr of it on Alibaba for 80€, transport comprised... The molecule seemed promising because it could act as antidepressive in 2 complemental chimical processes, that you can fine tune with the ingestion of pink (or is it white ?) grapefruit and other citrus having the same chimical properties, leading to the greater degradation or not of DXM while digesting, the product of degradation also having anti-depressive properties on its own, but in a different way. The package get unfortunatelly blocked at French custom border. Now it seems I'm blacklisted in european custom as most of my order from China is systematically blocked. Here are some ressources : https://www.vice.com/en_us/article/9kzkje/dxm-cough-syrup-antidepressant-ketamine https://www.vice.com/en_us/article/9kzkje/dxm-cough-syrup-an... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398352/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398352/ https://sci-hub.tw/https://doi.org/10.1016/j.mehy.2011.02.003 https://sci-hub.tw/https://doi.org/10.1016/j.mehy.2011.02.00... https://mhc.cpnp.org/doi/full/10.9740/mhc.2019.03.076 https://mhc.cpnp.org/doi/full/10.9740/mhc.2019.03.076 Edit : Typo and removed an irrelevant reference.

WalterSear 7y ago

60mg every 3 days. I don't believe it's a common treatment modality - though my doctor has some other patients on it. The primary sensation I experience on an ongoing basis is the the elimination of the sensation of abstract physical pain that I experience with negative thoughts and mood. The process is not inherently anti-inflammatory: while high dose IV ketamine are used to treat inflammatory diseases, as I understand it, the dose I'm taking doesn't directly affect inflammation, but works by modulating glutamate signaling. The relationship between inflammation and mood isn't yet clear to science, but we know that it is likely involved in many cases of treatment resistant depression. Third hand, I know of people who are taking black market ketamine to treat depression, though I don't know what schedule they are following. There's a definite 'cliff' at the third day, as the ketamine wears off.

missosoup 7y ago
Rather unique and interesting case. I'm glad you found something that works for you.
w1nst0nsm1th 7y ago
60mg every 3 days. That's was the protocol I followed with auto-prescribed ketamine. Then I wanted to try every NMDA antagonists existing other than ketamine, like memantine, used as alzheimer treatment, but also ephenidine, diphenidine, methoxphenidine and later MXPr, all present in research chemical scene. Then I heard about dextromethorphan (DXM) on a drug forum about anecdotical experience on its potential as antidepressive and even read a scientific paper about it. It is used as composent in cough syrop worldwide and, according to country laws, available without legal restriction or not, mainly because it is reputed for its potential of abuse for its dissociative effect. In Belgium, it is supposed to be unrestricted for possession and use and so I bought 100gr of it on Alibaba for 80€, transport comprised... The molecule seemed promising because it could act as antidepressive in 2 complemental chimical processes, that you can fine tune with the ingestion of pink (or is it white ?) grapefruit and other citrus having the same chimical properties, leading to the greater degradation or not of DXM while digesting, the product of degradation also having anti-depressive properties on its own, but in a different way. The package get unfortunatelly blocked at French custom border. Now it seems I'm blacklisted in european custom as most of my order from China is systematically blocked. Here are some ressources : https://www.vice.com/en_us/article/9kzkje/dxm-cough-syrup-antidepressant-ketamine https://www.vice.com/en_us/article/9kzkje/dxm-cough-syrup-an... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398352/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398352/ https://sci-hub.tw/https://doi.org/10.1016/j.mehy.2011.02.003 https://sci-hub.tw/https://doi.org/10.1016/j.mehy.2011.02.00... https://mhc.cpnp.org/doi/full/10.9740/mhc.2019.03.076 https://mhc.cpnp.org/doi/full/10.9740/mhc.2019.03.076 Edit : Typo and removed an irrelevant reference.