8 ms·

The Ketamine Chronicles, April 2019

93 points by keypusher 7y ago

deleted 7y ago
[deleted]
whalesalad 7y ago
This was written a month after the treatment ended. I would love to hear how the author is doing now, because all of my research has conluded that this therapy -- while really powerful -- does not make a lasting and permanent change in your brain. I would really like to give it a shot -- but for a couple thousand bucks for the initial series of treatments, I would hope that the change is more lasting.
- callesgg 7y ago
  It holds for a few months. During that time you can get your shit together. Try to figure out what is triggering the depression and try to change that thing. If you fail you can just do it again.
  - heavenlyblue 7y ago
    To be fair, I would much rather have a ket party once in a while than be on amohetamines (Adderall) for the rest of my life; which is an accepted treatment for certain disabilities.
  - sneak 7y ago
    In many cases, depression is not triggered by some external influence.
    - callesgg 7y ago
      There is always an internal trigger. The intersection between internal and external is not so clear. What the ultimate cause is, who knows. Is the idea of a ultimate cause is even a valid idea? Personally I don't think so.
    - solinent 7y ago
      The issue with saying this is we should probably have many words for different types of depression. Probably not only split on this one variate (externally or internally triggered), but it means that certain types of depression are usually triggered externally and certain types not externally. It's like saying that "in some cases, a broken leg is not triggered by some external influence". Sure, you could develop some bone density issue and break a leg when walking normally, so we tend to distinguish treatment of these cases--we may recommend a more permanent solution for someone who is prone to breaking their leg. How can we even falsify your statement? To do so would require self-reports or some sort of real-time 24/7 measurement of the brain, the first doesn't really falsify anything, and the second is not very viable at the present. Self-reports can easily lie. They also may simply not remember, or be in denial.
  - smolder 7y ago
    And the medical insurers and providers get to make hundreds of dollars for every $5 of ketamine dispensed, so it's win-win.
  - rincebrain 7y ago
    Two remarks: - It doesn't necessarily hold for a few months. For some people, it's not too much longer than an infusion session; for others, they might not even need the "booster" infusions some get. - There's some patients for whom the "tolerance" for the antidepressant effect doesn't go away even after O(years) without taking it when it initially worked and then stopped, so you can't necessarily just do it again. (Source for this one is that it happened to me, and did not return while going as high a dose as the doctor was comfortable with.)
- TheDong 7y ago
  The author's active on instagram (linked from their medium profile), and has more recent writing there. From that, it sounds like they don't feel as if they've regressed. For example, on Nov 27th, they wrote '[this year] I successfully treated depression with Ketamine'. It's possible that they're not talking candidly on the shorter-form of an instagram post, but it's at least a sign that maybe it stuck, otherwise that phrasing would probably be a bit less positive.
  - account73466 7y ago
    Possible. However it is also possible that saying that would lead to less clicks on his instagram's donate link.
    - VistaBrokeMyPC 7y ago
      IMO there's a decent probability that's the reason... The treatments cost an arm, a leg, and one kidney.
      - sneak 7y ago
        Only via the licensed path. The amount of ketamine his blog post talks about him receiving actually costs less than $100.
      - mistermann 7y ago
        Assuming he wasn't being dishonest in the discussion of his current financial state, this angle seems off the mark.
  - Erik816 7y ago
    The entire first section of the article is about how good the author was at pretending to be happy. Since projecting a happy image is also the main point of Instagram for most people, I'd be hesitant to assume everything is fine based on a few posts.
- VistaBrokeMyPC 7y ago
  I did six infusions at 1.25mg/kg (because I have a high tolerance to.. Everything it seems?) and it lasted a few weeks~a month and a half. I did another batch of sessions 3 months later and the results were the same. I now take it as an intranasal spray at a much lower dose every other day. It makes me mentally exhausted for a few hours afterwards, but at least it provides me some ease on the mental burden I have. I've been in psychotherapy twice a week for nearly ten years, tried literally every drug aside from classic MAOIs and ECT. I've debated TMS/rTMS, but I'm concerned about the memory loss that I've read about and heard first hand accounts of from friends in similar situations. Obviously everyone is different and YMMV, but for me- ketamine has been the only thing that made a real impact, bonus was the lack of nasty antidepressant side effects (I'm still taking an SSRI, SNRI, and a mood stabilizer and I hate them). I'm hopeful that some of the new ketamine+___ compounds being created to extend the duration of the 'depression slightly lifted' feeling are successful and come to trial soon.
  - psv1 7y ago
    Have you tried or considered hallucinogens? I'm not suggesting that you do, just interested in your perspective considering how severe and long-lasting your depression seems to be.
    - VistaBrokeMyPC 7y ago
      I have, but I don't think I have the right mindset for tripping. Acid is totally out of the question for reasons related to an lsd abusing family member, but shrooms is still on the table
      - mistermann 7y ago
        Why do you say totally out of the question, is it basically a risk calculation?
  - cmrdporcupine 7y ago
    Last time this topic came up on HN this came up: https://en.wikipedia.org/wiki/Bupropion/dextromethorphan https://en.wikipedia.org/wiki/Bupropion/dextromethorphan Combination of Wellbutrin & Dextromethorphan -- which is a dissociative with some side-effects similar to Ketamine. It's in trial for severe depression treatment. 15mg of DXM (which you can buy at any drug store) combined with 150mg Wellbutrin (which you can get your dr. to prescribe to you.) Could be worth a try...
- mattnewport 7y ago
  This article from September suggests he still has depressive episodes: https://psiloveyou.xyz/depression-doesnt-ask-if-now-s-a-good-time-331b9015679b https://psiloveyou.xyz/depression-doesnt-ask-if-now-s-a-good...
empath75 7y ago
I did a bunch of ketamine and mdma in the early 2000s. They’re miracle substances and they changed my life in positive ways that I can’t even begin to talk about, but they are not cures for depression. Eventually the effect wears off and all of the stuff that bothered you before will start bothering you again. If you don’t figure out how to give your life meaning, the drugs aren’t going to do it for you. They’ll give you time and space to do it, but you really need to make the best of the opportunity while you have it. This guy’s blog post sounds exactly like a hundred conversations I had with people I met at raves. We all knew that it was making our lives better, but most of us were broken people going into the scene and at best a lot of us were slightly less broken coming out of it. Someone I’m sure is going to say that it’s a medicine and not a party drug now because a nurse is giving it and someone wrote a prescription, but it’s the same drug with the same effect. I’m not saying that to be judge-y. I think people should have a right to improve themselves or have fun anyway they want to without hurting any body. Just that if this thing cured depression, there would have been a whole lot of ravers that were permanently cured and I know from personal experience that it isn’t the case. I’d really hate to see people try this thinking they’re going to be happy and be even worse off after the fog settles in again.
- kaens 7y ago
  Yeah. I have a similar background to you with this stuff and the first major thing that popped into my head while reading this article was "not enough time has passed since you experienced this"
- kaikai 7y ago
  Your anecdata doesn’t match up with current ketamine research. The protocol for depression is really different than using it for a party drug. Same for mdma for things like ptsd- it’s paired with therapy that helps you work through things. You’re right that just taking drugs isn’t enough, but please don’t discount medical treatment that changes the lives of many people.
  - empath75 7y ago
    Rubbing ‘medical’ on something doesn’t magically change how it works. And it’s pretty much impossible to take mdma and not engage in talk therapy. I had conversations that went from favorite djs to the time they were raped in middle school with complete strangers. And then you go out and dance. I don’t think a hospital is going to improve the situation much. It’s just a loophole people have to go through to make it socially acceptable.
cmrdporcupine 7y ago
Long term use of ketamine can cause irreversible damage to the urinary tract. I'm not how well it's been studied, and I doubt it's known how much and use for how long causes this damage. It is best to be careful. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544340/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544340/ https://www.sciencedaily.com/releases/2016/03/160318090442.htm https://www.sciencedaily.com/releases/2016/03/160318090442.h... https://www.nursingtimes.net/clinical-archive/medicine-management/addressing-ketamine-bladder-syndrome-19-06-2011/ https://www.nursingtimes.net/clinical-archive/medicine-manag...
- 0xdeadb00f 7y ago
  This is very true for long term recreational doses and is often overlooked by many.
mistermann 7y ago
Any given document, or event in reality, can be read (interpreted) from a wide variety of perspectives, often with completely contradictory conclusions. Individuals reading this article from a purely logical, scientific materialist perspective, may form drastically different conclusions than those reading from the wide variety of different possible perspectives. And that's fine, it is the nature of humanity. But it seems very plausible to me that an inability (or unwillingness) of people to interpret ideas from multiple perspectives, is not fine. There are many problems in the world (yes, I know, this has always been the case...from a binary perspective, but that is only one perspective on it). The world is complex, and getting more complex. Perhaps the manner in which we currently evaluate the world lacks the dimensional complexity required to manage it in a reasonably optimum way? If(!) this was the case, what might that look like? What would discussions about reality look like? Is it possible that we might be in a situation similar to this? How might we know?
- mistermann 7y ago
  What that I've written is offensive or incorrect downvoters? You have a sense of righteousness, but do you have any courage? How do you know your ideas are correct if you never put them to the test? Hiding in a mob seems like a waste of something precious.
  - narag 7y ago
    I'm curious, how is your comment related to the article? Or in other words, don't you think your comment could be posted in any other entry and would be equally (ir)relevant? It's not that it's incorrect, more like it's kind of non-sequitur-ish, as if you omitted a part of it that connects the comment to what it's commenting on.
    - mistermann 7y ago
      My comment could indeed be posted in many other threads and be relevant, but not equally relevant. I felt this article did a well above-average job communicating details about what alternate states of consciousness are like, and how it can fundamentally change your thinking, in at least a semi-permanent manner. However, most of the comments on the article seem to be written very much from a scientific materialist perspectives, and are often utterly lacking in epistemic humility. Take the very first sentence from the top voted comment in the thread: >> I did a bunch of ketamine and mdma in the early 2000s. They’re miracle substances and they changed my life in positive ways that I can’t even begin to talk about, but they are not cures for depression. Eventually the effect wears off and all of the stuff that bothered you before will start bothering you again. This is fairly representative of many comments. Some obvious questions: - how does he know this to be true? - it may be pedantically true that they aren't 100% cures on their own for every single person, but might they get us 75% or more of the way there for most people? - it's true that the effect diminishes over time, but do you completely revert to the previous state? Can the improved state be maintained with ongoing usage (something which is rarely disputed for mainstream pharmaceuticals, but often seems to be considered unacceptable for psychedelics) >> If you don’t figure out how to give your life meaning, the drugs aren’t going to do it for you. This is another one of those comments that may be pedentically technically true, if read very generously, but also very misleading. Might the subconscious mind choose casual expressions like "do it for you" to maximize persuasion, while minimizing opportunity for criticism ("hey, I was speaking colloquially, man"). The next sentence appears to undo much of the harm, but what impression is left in the mind of an unknowing reader? Who knows. Does it matter? I think it probably does, and maybe a lot. I would argue that result of this style of speaking is a kind of epistemological chaos - we are discussing substances that may finally offer at least a partial solutions for much of what ails the world, but the status quo aggregate opinion (~nothing particularly noteworthy to be seen here, just woo woo, move along citizen) in most threads like this seems completely incorrect to me. At least, there is a serious lack of epistemic humility - strong, conclusive opinions, on topics where the facts are currently unknown - literally. And no one can admit it (that such things are unknown). To me, this is a utterly surreal state of affairs, and it is incredibly frustrating to experience this, and then open the next thread on HN and hear people complaining about problem-of-the-day that could be fixed if group <x> would "just" stop being "stupid". The irony is bitter sweet. >> Someone I’m sure is going to say that it’s a medicine and not a party drug now because a nurse is giving it and someone wrote a prescription, but it’s the same drug with the same effect. Again, pedentically technically true as written (maybe, if read generously), but completely overlooks the essentially undisputed (among knowledgeable people) notion of the importance of set and setting. Ignorant and misleading comments like "not a party drug now because a nurse is giving it and someone wrote a prescription" getting heavily upvoted kind of disgusts me to be honest. I am of the opinion that that thinking like this, and the people that support it, are preventing the world from improving. And most likely, many of the people complaining about faults in the world are the very same people who refuse to consider alternative ways of thinking about issues, and downvote anyone who makes such a suggestion. These substances, and articles like this, are finally giving us some new insights into possible underlying reasons of why people behave like they do, and believe the things they do (anti-vaxx, climate change deniers, I have no reason to be happy, etc), in spite of overwhelming and "obvious" (or so it seems) evidence to the contrary. And it seems if you try to point this possibility out to people, they will get angry at you. What could explain these effects (of the substances), and this behavior (~refusal to even consider certain possibilites)? How about this: the human ego. The human ego often doesn't like to be disagreed with. This is clear as day, if one is willing to look. But it seems like the ego will only allow this on certain topics, almost as kind of a self-defense mechanism. > It's not that it's incorrect, more like it's kind of non-sequitur-ish, as if you omitted a part of it that connects the comment to what it's commenting on. I don't think it's so much that it's a non-sequitur (it isn't), but perhaps that it seems (but actually isn't, if one is willing to think, which is my point) irrelevant (or blatantly obvious) to the degree that it is considered useless. With any topic, if people refuse to use their minds (and that very much is the case), there's a good chance they won't understand the material. Mocking various out-groups for refusing to acknowledge facts and think properly is a popular pastime on HN, but rare is the individual who is able to even consider the possibility that they suffer from the very same psychological affliction.
dundercoder 7y ago
I’ve been on prescribed ketamine for over a year and I can’t even begin to articulate the improvement I’ve made.
- leoh 7y ago
  What is the protocol you are using (dose, frequency, method)?
  - dundercoder 7y ago
    1.85mg/kg injection IM once or twice a month in office, then 200mg sublingual or 80mg intranasal at home twice a week. Improvement has been steady for over a year.
throw12345sss 7y ago
I took twice, three times racemic pills and then a couple grams of esketamine in five or six sessions, everything illegal. Racemic was funny. Esketamine is extra-weird, I felt the movie on tv was real and I was chatting with Antonio Banderas, an undercover CIA operative. Later my body felt as a paper balloon. No K-hole though. A year later: I haven't smoke weed since. I just got uninterested. No more ketamine, but I'm considering buying again. For months after the binge, alcohol didn't get me drunk, that was weird. Anxiety, a little better. Block was no better.
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93 points by keypusher 7y ago

deleted 7y ago

[deleted]

This was written a month after the treatment ended. I would love to hear how the author is doing now, because all of my research has conluded that this therapy -- while really powerful -- does not make a lasting and permanent change in your brain. I would really like to give it a shot -- but for a couple thousand bucks for the initial series of treatments, I would hope that the change is more lasting.

callesgg 7y ago
It holds for a few months. During that time you can get your shit together. Try to figure out what is triggering the depression and try to change that thing. If you fail you can just do it again.
- heavenlyblue 7y ago
  To be fair, I would much rather have a ket party once in a while than be on amohetamines (Adderall) for the rest of my life; which is an accepted treatment for certain disabilities.
- sneak 7y ago
  In many cases, depression is not triggered by some external influence.
  - callesgg 7y ago
    There is always an internal trigger. The intersection between internal and external is not so clear. What the ultimate cause is, who knows. Is the idea of a ultimate cause is even a valid idea? Personally I don't think so.
  - solinent 7y ago
    The issue with saying this is we should probably have many words for different types of depression. Probably not only split on this one variate (externally or internally triggered), but it means that certain types of depression are usually triggered externally and certain types not externally. It's like saying that "in some cases, a broken leg is not triggered by some external influence". Sure, you could develop some bone density issue and break a leg when walking normally, so we tend to distinguish treatment of these cases--we may recommend a more permanent solution for someone who is prone to breaking their leg. How can we even falsify your statement? To do so would require self-reports or some sort of real-time 24/7 measurement of the brain, the first doesn't really falsify anything, and the second is not very viable at the present. Self-reports can easily lie. They also may simply not remember, or be in denial.
- smolder 7y ago
  And the medical insurers and providers get to make hundreds of dollars for every $5 of ketamine dispensed, so it's win-win.
- rincebrain 7y ago
  Two remarks: - It doesn't necessarily hold for a few months. For some people, it's not too much longer than an infusion session; for others, they might not even need the "booster" infusions some get. - There's some patients for whom the "tolerance" for the antidepressant effect doesn't go away even after O(years) without taking it when it initially worked and then stopped, so you can't necessarily just do it again. (Source for this one is that it happened to me, and did not return while going as high a dose as the doctor was comfortable with.)
TheDong 7y ago
The author's active on instagram (linked from their medium profile), and has more recent writing there. From that, it sounds like they don't feel as if they've regressed. For example, on Nov 27th, they wrote '[this year] I successfully treated depression with Ketamine'. It's possible that they're not talking candidly on the shorter-form of an instagram post, but it's at least a sign that maybe it stuck, otherwise that phrasing would probably be a bit less positive.
- account73466 7y ago
  Possible. However it is also possible that saying that would lead to less clicks on his instagram's donate link.
  - VistaBrokeMyPC 7y ago
    IMO there's a decent probability that's the reason... The treatments cost an arm, a leg, and one kidney.
    - sneak 7y ago
      Only via the licensed path. The amount of ketamine his blog post talks about him receiving actually costs less than $100.
    - mistermann 7y ago
      Assuming he wasn't being dishonest in the discussion of his current financial state, this angle seems off the mark.
- Erik816 7y ago
  The entire first section of the article is about how good the author was at pretending to be happy. Since projecting a happy image is also the main point of Instagram for most people, I'd be hesitant to assume everything is fine based on a few posts.
VistaBrokeMyPC 7y ago
I did six infusions at 1.25mg/kg (because I have a high tolerance to.. Everything it seems?) and it lasted a few weeks~a month and a half. I did another batch of sessions 3 months later and the results were the same. I now take it as an intranasal spray at a much lower dose every other day. It makes me mentally exhausted for a few hours afterwards, but at least it provides me some ease on the mental burden I have. I've been in psychotherapy twice a week for nearly ten years, tried literally every drug aside from classic MAOIs and ECT. I've debated TMS/rTMS, but I'm concerned about the memory loss that I've read about and heard first hand accounts of from friends in similar situations. Obviously everyone is different and YMMV, but for me- ketamine has been the only thing that made a real impact, bonus was the lack of nasty antidepressant side effects (I'm still taking an SSRI, SNRI, and a mood stabilizer and I hate them). I'm hopeful that some of the new ketamine+___ compounds being created to extend the duration of the 'depression slightly lifted' feeling are successful and come to trial soon.
- psv1 7y ago
  Have you tried or considered hallucinogens? I'm not suggesting that you do, just interested in your perspective considering how severe and long-lasting your depression seems to be.
  - VistaBrokeMyPC 7y ago
    I have, but I don't think I have the right mindset for tripping. Acid is totally out of the question for reasons related to an lsd abusing family member, but shrooms is still on the table
    - mistermann 7y ago
      Why do you say totally out of the question, is it basically a risk calculation?
- cmrdporcupine 7y ago
  Last time this topic came up on HN this came up: https://en.wikipedia.org/wiki/Bupropion/dextromethorphan https://en.wikipedia.org/wiki/Bupropion/dextromethorphan Combination of Wellbutrin & Dextromethorphan -- which is a dissociative with some side-effects similar to Ketamine. It's in trial for severe depression treatment. 15mg of DXM (which you can buy at any drug store) combined with 150mg Wellbutrin (which you can get your dr. to prescribe to you.) Could be worth a try...
mattnewport 7y ago
This article from September suggests he still has depressive episodes: https://psiloveyou.xyz/depression-doesnt-ask-if-now-s-a-good-time-331b9015679b https://psiloveyou.xyz/depression-doesnt-ask-if-now-s-a-good...

empath75 7y ago

I did a bunch of ketamine and mdma in the early 2000s. They’re miracle substances and they changed my life in positive ways that I can’t even begin to talk about, but they are not cures for depression. Eventually the effect wears off and all of the stuff that bothered you before will start bothering you again. If you don’t figure out how to give your life meaning, the drugs aren’t going to do it for you. They’ll give you time and space to do it, but you really need to make the best of the opportunity while you have it. This guy’s blog post sounds exactly like a hundred conversations I had with people I met at raves. We all knew that it was making our lives better, but most of us were broken people going into the scene and at best a lot of us were slightly less broken coming out of it. Someone I’m sure is going to say that it’s a medicine and not a party drug now because a nurse is giving it and someone wrote a prescription, but it’s the same drug with the same effect. I’m not saying that to be judge-y. I think people should have a right to improve themselves or have fun anyway they want to without hurting any body. Just that if this thing cured depression, there would have been a whole lot of ravers that were permanently cured and I know from personal experience that it isn’t the case. I’d really hate to see people try this thinking they’re going to be happy and be even worse off after the fog settles in again.

kaens 7y ago
Yeah. I have a similar background to you with this stuff and the first major thing that popped into my head while reading this article was "not enough time has passed since you experienced this"
kaikai 7y ago
Your anecdata doesn’t match up with current ketamine research. The protocol for depression is really different than using it for a party drug. Same for mdma for things like ptsd- it’s paired with therapy that helps you work through things. You’re right that just taking drugs isn’t enough, but please don’t discount medical treatment that changes the lives of many people.
- empath75 7y ago
  Rubbing ‘medical’ on something doesn’t magically change how it works. And it’s pretty much impossible to take mdma and not engage in talk therapy. I had conversations that went from favorite djs to the time they were raped in middle school with complete strangers. And then you go out and dance. I don’t think a hospital is going to improve the situation much. It’s just a loophole people have to go through to make it socially acceptable.

cmrdporcupine 7y ago

Long term use of ketamine can cause irreversible damage to the urinary tract. I'm not how well it's been studied, and I doubt it's known how much and use for how long causes this damage. It is best to be careful. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544340/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544340/ https://www.sciencedaily.com/releases/2016/03/160318090442.htm https://www.sciencedaily.com/releases/2016/03/160318090442.h... https://www.nursingtimes.net/clinical-archive/medicine-management/addressing-ketamine-bladder-syndrome-19-06-2011/ https://www.nursingtimes.net/clinical-archive/medicine-manag...

0xdeadb00f 7y ago
This is very true for long term recreational doses and is often overlooked by many.

mistermann 7y ago

Any given document, or event in reality, can be read (interpreted) from a wide variety of perspectives, often with completely contradictory conclusions. Individuals reading this article from a purely logical, scientific materialist perspective, may form drastically different conclusions than those reading from the wide variety of different possible perspectives. And that's fine, it is the nature of humanity. But it seems very plausible to me that an inability (or unwillingness) of people to interpret ideas from multiple perspectives, is not fine. There are many problems in the world (yes, I know, this has always been the case...from a binary perspective, but that is only one perspective on it). The world is complex, and getting more complex. Perhaps the manner in which we currently evaluate the world lacks the dimensional complexity required to manage it in a reasonably optimum way? If(!) this was the case, what might that look like? What would discussions about reality look like? Is it possible that we might be in a situation similar to this? How might we know?

mistermann 7y ago
What that I've written is offensive or incorrect downvoters? You have a sense of righteousness, but do you have any courage? How do you know your ideas are correct if you never put them to the test? Hiding in a mob seems like a waste of something precious.
- narag 7y ago
  I'm curious, how is your comment related to the article? Or in other words, don't you think your comment could be posted in any other entry and would be equally (ir)relevant? It's not that it's incorrect, more like it's kind of non-sequitur-ish, as if you omitted a part of it that connects the comment to what it's commenting on.
  - mistermann 7y ago
    My comment could indeed be posted in many other threads and be relevant, but not equally relevant. I felt this article did a well above-average job communicating details about what alternate states of consciousness are like, and how it can fundamentally change your thinking, in at least a semi-permanent manner. However, most of the comments on the article seem to be written very much from a scientific materialist perspectives, and are often utterly lacking in epistemic humility. Take the very first sentence from the top voted comment in the thread: >> I did a bunch of ketamine and mdma in the early 2000s. They’re miracle substances and they changed my life in positive ways that I can’t even begin to talk about, but they are not cures for depression. Eventually the effect wears off and all of the stuff that bothered you before will start bothering you again. This is fairly representative of many comments. Some obvious questions: - how does he know this to be true? - it may be pedantically true that they aren't 100% cures on their own for every single person, but might they get us 75% or more of the way there for most people? - it's true that the effect diminishes over time, but do you completely revert to the previous state? Can the improved state be maintained with ongoing usage (something which is rarely disputed for mainstream pharmaceuticals, but often seems to be considered unacceptable for psychedelics) >> If you don’t figure out how to give your life meaning, the drugs aren’t going to do it for you. This is another one of those comments that may be pedentically technically true, if read very generously, but also very misleading. Might the subconscious mind choose casual expressions like "do it for you" to maximize persuasion, while minimizing opportunity for criticism ("hey, I was speaking colloquially, man"). The next sentence appears to undo much of the harm, but what impression is left in the mind of an unknowing reader? Who knows. Does it matter? I think it probably does, and maybe a lot. I would argue that result of this style of speaking is a kind of epistemological chaos - we are discussing substances that may finally offer at least a partial solutions for much of what ails the world, but the status quo aggregate opinion (~nothing particularly noteworthy to be seen here, just woo woo, move along citizen) in most threads like this seems completely incorrect to me. At least, there is a serious lack of epistemic humility - strong, conclusive opinions, on topics where the facts are currently unknown - literally. And no one can admit it (that such things are unknown). To me, this is a utterly surreal state of affairs, and it is incredibly frustrating to experience this, and then open the next thread on HN and hear people complaining about problem-of-the-day that could be fixed if group <x> would "just" stop being "stupid". The irony is bitter sweet. >> Someone I’m sure is going to say that it’s a medicine and not a party drug now because a nurse is giving it and someone wrote a prescription, but it’s the same drug with the same effect. Again, pedentically technically true as written (maybe, if read generously), but completely overlooks the essentially undisputed (among knowledgeable people) notion of the importance of set and setting. Ignorant and misleading comments like "not a party drug now because a nurse is giving it and someone wrote a prescription" getting heavily upvoted kind of disgusts me to be honest. I am of the opinion that that thinking like this, and the people that support it, are preventing the world from improving. And most likely, many of the people complaining about faults in the world are the very same people who refuse to consider alternative ways of thinking about issues, and downvote anyone who makes such a suggestion. These substances, and articles like this, are finally giving us some new insights into possible underlying reasons of why people behave like they do, and believe the things they do (anti-vaxx, climate change deniers, I have no reason to be happy, etc), in spite of overwhelming and "obvious" (or so it seems) evidence to the contrary. And it seems if you try to point this possibility out to people, they will get angry at you. What could explain these effects (of the substances), and this behavior (~refusal to even consider certain possibilites)? How about this: the human ego. The human ego often doesn't like to be disagreed with. This is clear as day, if one is willing to look. But it seems like the ego will only allow this on certain topics, almost as kind of a self-defense mechanism. > It's not that it's incorrect, more like it's kind of non-sequitur-ish, as if you omitted a part of it that connects the comment to what it's commenting on. I don't think it's so much that it's a non-sequitur (it isn't), but perhaps that it seems (but actually isn't, if one is willing to think, which is my point) irrelevant (or blatantly obvious) to the degree that it is considered useless. With any topic, if people refuse to use their minds (and that very much is the case), there's a good chance they won't understand the material. Mocking various out-groups for refusing to acknowledge facts and think properly is a popular pastime on HN, but rare is the individual who is able to even consider the possibility that they suffer from the very same psychological affliction.

dundercoder 7y ago

I’ve been on prescribed ketamine for over a year and I can’t even begin to articulate the improvement I’ve made.

leoh 7y ago
What is the protocol you are using (dose, frequency, method)?
- dundercoder 7y ago
  1.85mg/kg injection IM once or twice a month in office, then 200mg sublingual or 80mg intranasal at home twice a week. Improvement has been steady for over a year.

throw12345sss 7y ago

I took twice, three times racemic pills and then a couple grams of esketamine in five or six sessions, everything illegal. Racemic was funny. Esketamine is extra-weird, I felt the movie on tv was real and I was chatting with Antonio Banderas, an undercover CIA operative. Later my body felt as a paper balloon. No K-hole though. A year later: I haven't smoke weed since. I just got uninterested. No more ketamine, but I'm considering buying again. For months after the binge, alcohol didn't get me drunk, that was weird. Anxiety, a little better. Block was no better.

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