The top papers I included are purposefully recent as they are recent reviews on an emerging area of research. Having read a lot of papers this year, my conclus

The top papers I included are purposefully recent as they are recent reviews on an emerging area of research. Having read a lot of papers this year, my conclusion btw is actually that recent papers are much better than older papers. One, newer papers allow you to spelunk through older papers in the citation chain (all peer reviewed work has substantive reference lists), and two, and state of understanding of basic human biology is miniscule and for emerging topics (like chronic inflammation, or human metabolism) our understanding has changed enormously due to recent discoveries (at a much improving rate). As an FYI, the inflammasome wasn't even discovered until 2002 [1] so you can basically be guaranteed that any prior research is going to be missing some key context. This is repeated for many pathways and processes that we take for granted (and a lot of it has barely filtered out to clinical practice much less pop culture) and will this will be repeating itself for quite some time, since we're still discovering so many new things that turn our understanding of biology on its head (just a handful of examples off the top of my head: role of microbiota (the wild west!), vagus nerve communication, autophagy, epigenetics, circadian clocks, and yes, most of ketone metabolism, particularly BHB as a signaling molecule). [1] https://en.wikipedia.org/wiki/Inflammasome#History https://en.wikipedia.org/wiki/Inflammasome#History