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Coffee and coaine are not actually worlds apart in terms of mechanism of action, they both act on the same brain pathway though coffee has a limited ability to
by 1_over_n 7y ago
Coffee and coaine are not actually worlds apart in terms of mechanism of action, they both act on the same brain pathway though coffee has a limited ability to activate this pathway in comparison to cocaine.
- jcora 7y agoThis is a completely meaningless comparison. Even things that behave waaay more similar than cocaine and coffee in terms of brain chemistry can have even more disparate effects. And I was talking about the effects.
- 1_over_n 7y agoThis meaningless comparison is a fundamental concept in psychopharmacology. Different substances can have different effects whilst acting on the same pathway. And to your point re: "effects"it should be noted the SAME substance can have very different effects (biphasic effects) depending on dose (alcohol being the key exmaple). https://en.wikipedia.org/wiki/Mesolimbic_pathway https://en.wikipedia.org/wiki/Mesolimbic_pathway https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-17-4 https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0... https://www.ncbi.nlm.nih.gov/pubmed/9884132 https://www.ncbi.nlm.nih.gov/pubmed/9884132