But isn't the net effect of that still going to be making men more sensitive to estrogen? I don't know if it's comparable, but my understanding is that over ti

But isn't the net effect of that still going to be making men more sensitive to estrogen? I don't know if it's comparable, but my understanding is that over time caffeine's binding to adenosine receptors causes more receptors to be produced, leading to increased sensitivity to adenosine and so you get more drowsy than you otherwise would when caffeine's not present. If that same effect applies to estrogen receptors, that would make men more sensitive to estrogen?