4 ms·

Are there websites like StackOverflow where you find pharmaceutical receipes for acetylcysteine?

arcticfox 7y ago
I think the parent is a physicist, not a pharmacologist, but I'm curious about what exists in both physics and pharmacology so I hope people chime in on both.
- MereInterest 7y ago
  Physicist here. ENSDF (Evaluated Nuclear Structure Data File) is a fantastic resource for anything related to nuclear physics.
  - petschge 7y ago
    Person doing simulations in plasma physics / astro physics here. I google tons of stuff every day. And I have a hard copy of https://www.nrl.navy.mil/ppd/content/nrl-plasma-formulary https://www.nrl.navy.mil/ppd/content/nrl-plasma-formulary on my desk. And the PDF on just about any of my devices. Once every few years I ask the Navy for 20 copies and hand them out to grad students and colleagues.
- ISL 7y ago
  The Decay Chain article on Wikipedia is a go-to favorite of mine: https://en.wikipedia.org/wiki/Decay_chain https://en.wikipedia.org/wiki/Decay_chain The graphics for the natural decay chains are eminently-usable and teachable.
semi-extrinsic 7y ago
Not a medicinal chemist, but I think the general procedure for that is to do a google (or better, Google Scholar) search for "$chemicalName synthesis". Here you go: One-step synthesis of N-acetylcysteine and glutathione derivatives using the Ugi reaction https://www.sciencedirect.com/science/article/abs/pii/S0040402009005778 https://www.sciencedirect.com/science/article/abs/pii/S00404... I can't seem to find an openly available PDF, but you can search sci-hub to pirate that. From reading the abstract and the graphics, it doesn't exactly look like something you cook up in the kitchen. For instance they run the reaction in trifluoroethanol, which is flammable, toxic, irritant and possibly causes reduced fertility from exposure.
lilott8 7y ago
Not sure if you have access to it, but reaxsys[1] is an amazing database for stuff like this. I've used it many times for looking for (un)safe reaction paths for particular drugs. It looks like the ``free'' version might let you get a lot of information from it. Also, pubchem[2] might be of help as well. This is entirely free. [1]https://www.reaxys.com/ https://www.reaxys.com/ [2]https://pubchem.ncbi.nlm.nih.gov/ https://pubchem.ncbi.nlm.nih.gov/
refurb 7y ago
That's usually done by literature search, which nowadays, can be done online. You draw a structure and it will look up literature that reported that as a product. I haven't seen a website like stack overflow in the sense of posting questions like "How do I purify after this Beckmann rearrangement?"

I think the parent is a physicist, not a pharmacologist, but I'm curious about what exists in both physics and pharmacology so I hope people chime in on both.

MereInterest 7y ago
Physicist here. ENSDF (Evaluated Nuclear Structure Data File) is a fantastic resource for anything related to nuclear physics.
- petschge 7y ago
  Person doing simulations in plasma physics / astro physics here. I google tons of stuff every day. And I have a hard copy of https://www.nrl.navy.mil/ppd/content/nrl-plasma-formulary https://www.nrl.navy.mil/ppd/content/nrl-plasma-formulary on my desk. And the PDF on just about any of my devices. Once every few years I ask the Navy for 20 copies and hand them out to grad students and colleagues.
ISL 7y ago
The Decay Chain article on Wikipedia is a go-to favorite of mine: https://en.wikipedia.org/wiki/Decay_chain https://en.wikipedia.org/wiki/Decay_chain The graphics for the natural decay chains are eminently-usable and teachable.

semi-extrinsic 7y ago

Not a medicinal chemist, but I think the general procedure for that is to do a google (or better, Google Scholar) search for "$chemicalName synthesis". Here you go: One-step synthesis of N-acetylcysteine and glutathione derivatives using the Ugi reaction https://www.sciencedirect.com/science/article/abs/pii/S0040402009005778 https://www.sciencedirect.com/science/article/abs/pii/S00404... I can't seem to find an openly available PDF, but you can search sci-hub to pirate that. From reading the abstract and the graphics, it doesn't exactly look like something you cook up in the kitchen. For instance they run the reaction in trifluoroethanol, which is flammable, toxic, irritant and possibly causes reduced fertility from exposure.

lilott8 7y ago

Not sure if you have access to it, but reaxsys[1] is an amazing database for stuff like this. I've used it many times for looking for (un)safe reaction paths for particular drugs. It looks like the ``free'' version might let you get a lot of information from it. Also, pubchem[2] might be of help as well. This is entirely free. [1]https://www.reaxys.com/ https://www.reaxys.com/ [2]https://pubchem.ncbi.nlm.nih.gov/ https://pubchem.ncbi.nlm.nih.gov/

refurb 7y ago

That's usually done by literature search, which nowadays, can be done online. You draw a structure and it will look up literature that reported that as a product. I haven't seen a website like stack overflow in the sense of posting questions like "How do I purify after this Beckmann rearrangement?"