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I said they sold it as that, not that it was that and that was the source of the issue. “Delayed absorption as provided by OxyContin tablets, is believed to re

I said they sold it as that, not that it was that and that was the source of the issue. “Delayed absorption as provided by OxyContin tablets, is believed to reduce the abuse liability of a drug.” That's what the FDA allowed them to publish. Possibly the most dangerous single sentence in the history of medicines.

refurb 7y ago
Ahhh, that makes sense. It is actually true though. Delayed release would be expected to reduce abuse liability. That doesn’t mean OxyContin is not addictive, it just means it’s expected to be less addictive than immediate release oxycodone.
- jdblair 7y ago
  People figured out pretty quickly that if you crush the pills, you absorb the oxycodone quickly. It was the coating that delayed absorption.
  - FDSGSG 7y ago
    Are there any slow release drugs that you can't do this with? Shouldn't this be obvious to the doctors?
    - FussyZeus 7y ago
      As a general rule Doctors trust the documentation given to them by the pharmaceutical companies, which in turn is approved after several rounds with the FDA, so one would think that the documentation would be pretty reliable. The source of the issue really is just how hard Purdue was fudging their data. And I mean, you can say that a drug company shouldn't be the sole tester of it's own drugs and I'd agree with you, but good luck getting average people to want to pay for it by funding the FDA.
      - FDSGSG 7y ago
        I wonder if it is normal for slow release drugs to come with warnings telling you that you can crush them up and abuse them?
  - refurb 7y ago
    This is true, so users were pretty quickly able to get around it. Although manufacturers have created a tamper proof version, but that just led users to move to heroin.
    - FussyZeus 7y ago
      Yes and no. The first fault is that even the studies done by Purdue prior to release did not indicate anything close to the 1% addiction rate they advertised, it was more like 8-12%. The second, most Oxycontin users who aren't well off eventually move to heroin, because the effects are very similar, and the street price for Oxycontin is much higher. Ironically, where Marijuana was demonized for a nonexistent gateway property in the original war on drugs, Oxycontin was actually demonstrably a gateway drug for heroin. There's a very well researched episode of the podcast "Behind the Bastards" hosted by Robert Evans that drills down exactly into all of Purdue's dirty little secrets surrounding Oxycontin. Once you realized just how many numbers were fudged, how many studies fiddled with, it becomes clear just how much had to be made to go wrong in order for this epidemic to really kick off. It's quite damning.

refurb 7y ago

Ahhh, that makes sense. It is actually true though. Delayed release would be expected to reduce abuse liability. That doesn’t mean OxyContin is not addictive, it just means it’s expected to be less addictive than immediate release oxycodone.

jdblair 7y ago
People figured out pretty quickly that if you crush the pills, you absorb the oxycodone quickly. It was the coating that delayed absorption.
- FDSGSG 7y ago
  Are there any slow release drugs that you can't do this with? Shouldn't this be obvious to the doctors?
  - FussyZeus 7y ago
    As a general rule Doctors trust the documentation given to them by the pharmaceutical companies, which in turn is approved after several rounds with the FDA, so one would think that the documentation would be pretty reliable. The source of the issue really is just how hard Purdue was fudging their data. And I mean, you can say that a drug company shouldn't be the sole tester of it's own drugs and I'd agree with you, but good luck getting average people to want to pay for it by funding the FDA.
    - FDSGSG 7y ago
      I wonder if it is normal for slow release drugs to come with warnings telling you that you can crush them up and abuse them?
- refurb 7y ago
  This is true, so users were pretty quickly able to get around it. Although manufacturers have created a tamper proof version, but that just led users to move to heroin.
  - FussyZeus 7y ago
    Yes and no. The first fault is that even the studies done by Purdue prior to release did not indicate anything close to the 1% addiction rate they advertised, it was more like 8-12%. The second, most Oxycontin users who aren't well off eventually move to heroin, because the effects are very similar, and the street price for Oxycontin is much higher. Ironically, where Marijuana was demonized for a nonexistent gateway property in the original war on drugs, Oxycontin was actually demonstrably a gateway drug for heroin. There's a very well researched episode of the podcast "Behind the Bastards" hosted by Robert Evans that drills down exactly into all of Purdue's dirty little secrets surrounding Oxycontin. Once you realized just how many numbers were fudged, how many studies fiddled with, it becomes clear just how much had to be made to go wrong in order for this epidemic to really kick off. It's quite damning.