4 ms·

I guess. Versus comparing it to alcohol, anyway. However, in my experience, psilocybin is closer to THC than to LSD. But they're really very different experien

I guess. Versus comparing it to alcohol, anyway. However, in my experience, psilocybin is closer to THC than to LSD. But they're really very different experiences. Alcohol does accentuate psilocybin, acceptably. But combining marijuana with either, especially LSD, can be frightening. Your short term memory drops to a few seconds, so you can forget who (or even what) you are, where you are, etc. Some people panic, and fear that they'll never be sober again.

W4nn4B_h4x0r 7y ago
Is it a good idea to take any of these - alcohol, Marijuana, LSD, mushrooms - with antidepressants? That is, if you're on medication, should you stay away from all recreational drug use?
- tastyfreeze 7y ago
  The effects of serotonergic psychedelics(LSD, psilocybin, DMT) are reduced by SSRI medications.
  - mirimir 7y ago
    Yeah. I had stopped using LSD before using SSRIs. Later, I used to vacation in Amsterdam for the shrooms. But I'd go off the SSRI maybe a week or so before the trip.
- sibeliuss 7y ago
  It is imperative that you do not combine psychedelics with antidepressants! This can lead to dangerous side effects / behaviors! If you take a combination of drugs this is even more important to heed. The proper path is to wean yourself off of the antidepressants for the experience, and then only undertake the experience with an experienced sitter or guide.
  - Frondo 7y ago
    It absolutely depends on the anti-depressant. SSRIs, do not mix. NDRIs, lots of people report they're fine. Hopefully we'll get better data on what other chemicals are okay to mix as these things slowly become permitted to be the subjects of study.
  - xorfish 7y ago
    https://wiki.tripsit.me/images/3/3a/Combo_2.png https://wiki.tripsit.me/images/3/3a/Combo_2.png Psilocybins effect is enhanced by MAOI and decreaces by SSRIs. LSD effects are decreased by both. With other other psychedelics you have to be a bit carefull. You probably think of MDMA and MAOIs, this would be a dangerous combination.
    - mirimir 7y ago
      Yes, MAOI dramatically increase and prolong effects of DMT. And indeed, that's what ayahuasca (aka yage) is. Plus various mushrooms and other psychoactive stuff, depending on the preferences of the curandeiro/a (shaman) and the intended outcome.
- ssriuser123 7y ago
  It is worth investigating with caution the option of using recreational drugs alongside antidepressant medication. I take the SSRI Fluoxetine (Prozac) and have tried numerous psychedelic drugs while on that prescription drug. Before doing so I checked with my psychiatrist who did not believe there would be a great risk. My experience has generally been that psychedelics work (with the exception of MDMA) and there are no drawbacks to using them while on an SSRI. Of course, psychedelics do have risks and educated, responsible use is appropriate.
  - mirimir 7y ago
    What I've heard is that they work. But that you need higher doses than you would need if you weren't taking an SSRI.
Frondo 7y ago
I had an experience of total amnesia on LSD once. After a few minutes (objective, by a wall clock) of time-dilation experience (felt like 8 or 10 hours passing), I wandered upstairs and laid down on the bed. Again, a few minutes of closed-eye visuals that felt like hours passed, and when I opened my eyes, I had absolutely no idea who I was, even down to my name, where I lived, nothing. The only thing I could say was "I exist," without being able to qualify that in any way at all, and by staring at the room around me, "I'm in a room, seems to be in a city." Very, very strange experience. Suddenly, no more visuals, but it took the next few hours for details about myself, my hobbies, my work, etc., to start filtering back in.
- mirimir 7y ago
  Huh. Did you take any other drugs? I've experienced stuff like that at high LSD dosages, but it wasn't unpleasant. In fact, I liked it. It's what I meant by "ego death". That is, there's no awareness that an "I" exists. There's just stuff happening. Inside, outside, all the same. Just stuff. And then gradually, there's this internal dialog that starts talking about all the stuff. That is, consciousness, what I'm calling ego aka "I". With marijuana during LSD peaking, that happens abruptly. With sometimes considerable anxiety.
- eaenki 7y ago
  That sounds scary af
  - perl4ever 7y ago
    I've had modern anesthesia for surgery twice in my life, and that seems to operate mostly by temporarily eliminating your ability to form memories. I found that "scary af" even though it certainly worked as expected.
- spurgu 7y ago
  I had this on alcohol + an unhealthy dose of psilocybin, apart from the difference where the only thing I could think was "I don't even know what 'exist' means". Scary but luckily I had some close friends that were comforting me throughout the experience. For the most part though, my small experiments (LSD, mushrooms, DMT) have had a very positive and borderline revolutional effect on my outlook on life. Only time I've had negative experiences have been on mushrooms, both LSD and DMT have always been positive.

W4nn4B_h4x0r 7y ago

Is it a good idea to take any of these - alcohol, Marijuana, LSD, mushrooms - with antidepressants? That is, if you're on medication, should you stay away from all recreational drug use?

tastyfreeze 7y ago
The effects of serotonergic psychedelics(LSD, psilocybin, DMT) are reduced by SSRI medications.
- mirimir 7y ago
  Yeah. I had stopped using LSD before using SSRIs. Later, I used to vacation in Amsterdam for the shrooms. But I'd go off the SSRI maybe a week or so before the trip.
sibeliuss 7y ago
It is imperative that you do not combine psychedelics with antidepressants! This can lead to dangerous side effects / behaviors! If you take a combination of drugs this is even more important to heed. The proper path is to wean yourself off of the antidepressants for the experience, and then only undertake the experience with an experienced sitter or guide.
- Frondo 7y ago
  It absolutely depends on the anti-depressant. SSRIs, do not mix. NDRIs, lots of people report they're fine. Hopefully we'll get better data on what other chemicals are okay to mix as these things slowly become permitted to be the subjects of study.
- xorfish 7y ago
  https://wiki.tripsit.me/images/3/3a/Combo_2.png https://wiki.tripsit.me/images/3/3a/Combo_2.png Psilocybins effect is enhanced by MAOI and decreaces by SSRIs. LSD effects are decreased by both. With other other psychedelics you have to be a bit carefull. You probably think of MDMA and MAOIs, this would be a dangerous combination.
  - mirimir 7y ago
    Yes, MAOI dramatically increase and prolong effects of DMT. And indeed, that's what ayahuasca (aka yage) is. Plus various mushrooms and other psychoactive stuff, depending on the preferences of the curandeiro/a (shaman) and the intended outcome.
ssriuser123 7y ago
It is worth investigating with caution the option of using recreational drugs alongside antidepressant medication. I take the SSRI Fluoxetine (Prozac) and have tried numerous psychedelic drugs while on that prescription drug. Before doing so I checked with my psychiatrist who did not believe there would be a great risk. My experience has generally been that psychedelics work (with the exception of MDMA) and there are no drawbacks to using them while on an SSRI. Of course, psychedelics do have risks and educated, responsible use is appropriate.
- mirimir 7y ago
  What I've heard is that they work. But that you need higher doses than you would need if you weren't taking an SSRI.

Frondo 7y ago

I had an experience of total amnesia on LSD once. After a few minutes (objective, by a wall clock) of time-dilation experience (felt like 8 or 10 hours passing), I wandered upstairs and laid down on the bed. Again, a few minutes of closed-eye visuals that felt like hours passed, and when I opened my eyes, I had absolutely no idea who I was, even down to my name, where I lived, nothing. The only thing I could say was "I exist," without being able to qualify that in any way at all, and by staring at the room around me, "I'm in a room, seems to be in a city." Very, very strange experience. Suddenly, no more visuals, but it took the next few hours for details about myself, my hobbies, my work, etc., to start filtering back in.

mirimir 7y ago
Huh. Did you take any other drugs? I've experienced stuff like that at high LSD dosages, but it wasn't unpleasant. In fact, I liked it. It's what I meant by "ego death". That is, there's no awareness that an "I" exists. There's just stuff happening. Inside, outside, all the same. Just stuff. And then gradually, there's this internal dialog that starts talking about all the stuff. That is, consciousness, what I'm calling ego aka "I". With marijuana during LSD peaking, that happens abruptly. With sometimes considerable anxiety.
eaenki 7y ago
That sounds scary af
- perl4ever 7y ago
  I've had modern anesthesia for surgery twice in my life, and that seems to operate mostly by temporarily eliminating your ability to form memories. I found that "scary af" even though it certainly worked as expected.
spurgu 7y ago
I had this on alcohol + an unhealthy dose of psilocybin, apart from the difference where the only thing I could think was "I don't even know what 'exist' means". Scary but luckily I had some close friends that were comforting me throughout the experience. For the most part though, my small experiments (LSD, mushrooms, DMT) have had a very positive and borderline revolutional effect on my outlook on life. Only time I've had negative experiences have been on mushrooms, both LSD and DMT have always been positive.