4 ms·
In UK there was just recently published Guidelines for [1] Safe prescribing of fluoroquinolones. 'Do not use fluoroquinolones in patients with known aortic ane
by michalxnet 7y ago
In UK there was just recently published Guidelines for [1] Safe prescribing of fluoroquinolones.
'Do not use fluoroquinolones in patients with known aortic aneurysm, aortic dissection or history of serious side effects related to quinolone treatment (including tendon disease/disorder) unless there are no other treatment options available'
'Patients should be counselled to discontinue fluoroquinolone treatment and seek urgent medical attention at the first sign of:
- Tendon pain or inflammation (particularly in shoulder or ankle)
- Symptoms of neuropathy such as pain, burning, pins & needles, tingling, numbness or weakness
- Sudden-onset of severe and constant abdominal, chest or back pain
1. https://www.ncl-mon.nhs.uk/wp-content/uploads/Guidelines/5_Fluoroquinolones_Safe_Prescribing_Position_Statement.pdf https://www.ncl-mon.nhs.uk/wp-content/uploads/Guidelines/5_F...
- dmead 7y agoSo basically it fucks with your connective tissue?
- dfsegoat 7y ago> The histopathologic findings [of the tendons] include degenerative lesions, fissures, interstitial edema without cellular infiltration, necrosis and neovascularization [1] Basically it dissolves, and the achilles tendon is the most common rupture, at least with cipro. 1. https://www.ncbi.nlm.nih.gov/pubmed/22035890 https://www.ncbi.nlm.nih.gov/pubmed/22035890
- Engineering-MD 7y agoAs far as I am aware, the association with aortic aneurysm is weak ( I think a relative risk of 2) from an associate only study (ie no causation proven). So take these with a pinch of salt, especially for those with a penicillin allergy as covering some bugs without penicillins or flouroquinolones can be tricky.