I consider myself extremely risk averse, and would probably agree with you on most things. But with unbeatable Major Depression you are dealing with a signific

I consider myself extremely risk averse, and would probably agree with you on most things. But with unbeatable Major Depression you are dealing with a significant suicide risk, and the risk to your legal status may be worth the benefit to your overall happiness. People who want to replace a little Prozac with Psilocybin can afford to wait 10-15 years for treatments to become standardized, legal and affordable. I spent 15 years assuming that I would kill myself someday, and basically all of life was a delaying action to put suicide off as long as possible. So for me taking the plunge into illegal self treatment was worth it. A yearly Ayahusca session for me does more to combat depression that years of therapy and legal medications.