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> >50ug <400ug That is a huge difference. 400ug is a big dose and 50ug barely noticable. Anyone reading this without experience going for 400 is going to get

> >50ug <400ug That is a huge difference. 400ug is a big dose and 50ug barely noticable. Anyone reading this without experience going for 400 is going to get knocked for six

lm28469 7y ago
Ah yeah definitely don't go for 400u for your first time. I assume no one would think "that random dude on HN recommended 400ug" and go for it without more research though. 50-150 is more manageable for a beginner.
- AnthonBerg 7y ago
  The 150 end of the range as a first time can be manageable for some and can be quite intense for others. Some research suggests a “30-40 microgram trip first, then a 60-80 microgram before anything larger, then a 120-140 microgram before anything larger, then either stopping there (this was the dosage that resulted in the highest increase in well-being) or doing a 170-240 microgram trip.” — https://tripsafe.org/how-to-take-lsd/#start-small https://tripsafe.org/how-to-take-lsd/#start-small
  - filleokus 7y ago
    Another issue is the, albeit anecdotal, inaccuracy of LSD concentration in black market products. If you are aiming for a 100 ug dose, and blotters marketed as 100 ug can range from 50-150 ug, its quite hard to do proper dosage. Darknet markets have however probably improved the situation with accountability and reviews from customer.
    - cuspycode 7y ago
      Also, the pharmaceutical effect of any given amount depends on body weight and various other factors. So the exact amount needed for a particular trip level is different from person to person.
  - lmpostor 7y ago
    75-125 is an actual trip. Anything less than that you're not going to get the full psychedelic experience. We can debate the effects of microdosing, but 100-150ug has been a gold standard for decades for a reason.
    - AnthonBerg 7y ago
      I don’t disagree! :) I think you’d find the graphs in the tripsafe link interesting - they show a relationship of starting dose size and rampup vs. lasting benefits. Also some statistics of how many participants felt high anxiety per starting dose. The most significant lasting benefits seemed to come from initially low and then escalating doses. iow it seems like a small dose allows people to process better. Open more up? Be swept less away by the experience and work more within their personal selves’ substance and experience?
      - lmpostor 7y ago
        I mean first off that is only in comparison to a dosage schedule of the reverse amount. I'm just arguing that it would make more sense to start at 80-110-140-170 etc because below that is placebo.
__blockcipher__ 7y ago
Just wanted to mention that 50ug of LSD tartrate is very noticeable. A 100ug tab is a surprisingly strong tab. Source: have worked directly with LSD crystal in the past. (Unfortunately anecdotes are king when it comes to illicit drugs otherwise I’d be able to cite an actual external source)

> >50ug <400ug That is a huge difference. 400ug is a big dose and 50ug barely noticable. Anyone reading this without experience going for 400 is going to get knocked for six

lm28469 7y ago

Ah yeah definitely don't go for 400u for your first time. I assume no one would think "that random dude on HN recommended 400ug" and go for it without more research though. 50-150 is more manageable for a beginner.

AnthonBerg 7y ago
The 150 end of the range as a first time can be manageable for some and can be quite intense for others. Some research suggests a “30-40 microgram trip first, then a 60-80 microgram before anything larger, then a 120-140 microgram before anything larger, then either stopping there (this was the dosage that resulted in the highest increase in well-being) or doing a 170-240 microgram trip.” — https://tripsafe.org/how-to-take-lsd/#start-small https://tripsafe.org/how-to-take-lsd/#start-small
- filleokus 7y ago
  Another issue is the, albeit anecdotal, inaccuracy of LSD concentration in black market products. If you are aiming for a 100 ug dose, and blotters marketed as 100 ug can range from 50-150 ug, its quite hard to do proper dosage. Darknet markets have however probably improved the situation with accountability and reviews from customer.
  - cuspycode 7y ago
    Also, the pharmaceutical effect of any given amount depends on body weight and various other factors. So the exact amount needed for a particular trip level is different from person to person.
- lmpostor 7y ago
  75-125 is an actual trip. Anything less than that you're not going to get the full psychedelic experience. We can debate the effects of microdosing, but 100-150ug has been a gold standard for decades for a reason.
  - AnthonBerg 7y ago
    I don’t disagree! :) I think you’d find the graphs in the tripsafe link interesting - they show a relationship of starting dose size and rampup vs. lasting benefits. Also some statistics of how many participants felt high anxiety per starting dose. The most significant lasting benefits seemed to come from initially low and then escalating doses. iow it seems like a small dose allows people to process better. Open more up? Be swept less away by the experience and work more within their personal selves’ substance and experience?
    - lmpostor 7y ago
      I mean first off that is only in comparison to a dosage schedule of the reverse amount. I'm just arguing that it would make more sense to start at 80-110-140-170 etc because below that is placebo.

__blockcipher__ 7y ago

Just wanted to mention that 50ug of LSD tartrate is very noticeable. A 100ug tab is a surprisingly strong tab. Source: have worked directly with LSD crystal in the past. (Unfortunately anecdotes are king when it comes to illicit drugs otherwise I’d be able to cite an actual external source)