3 ms·

Sample size is 998 and is only women. The study: https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awz348/5628036 https://academic.oup.

Sample size is 998 and is only women. The study: https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awz348/5628036 https://academic.oup.com/brain/advance-article-abstract/doi/... >"Evidence suggests exposure to particulate matter with aerodynamic diameter <2.5 μm (PM2.5) may increase the risk for Alzheimer’s disease and related dementias. Whether PM2.5 alters brain structure and accelerates the preclinical neuropsychological processes remains unknown. " I'm sure air pollution is pretty bad for you but this seems statistically insignificant in the grand scheme of things. Great headline for New Yorkers who need something else to be afraid of.

VC999 7y ago
So you would think that men are imune to pollution.
- alwaysanagenda 7y ago
  I would think that a study on the effect of pollution on the brain should include men and women, because it's clearly unknown if it can affect women or men more strongly, or the same, or somehow different, depending on a myriad biological factors which differentiates between the sexes. I'm just pointing out that the data is absent.
- khuey 7y ago
  Even if men were immune poisoning only half the population still seems like a bad idea.
WhompingWindows 7y ago
Your quote is only from first half of the abstract... You haven't even quoted any statistics, where are you getting "statistically insignificant" from? The article itself shows that there is an association between AD and long-term PM2.5. See below for some actual statistical findings: "In multilevel structural equation models, PM2.5 was associated with greater declines in immediate recall and new learning, but no association was found with decline in delayed-recall or composite scores. For each interquartile increment (2.81 μg/m3) of PM2.5, the annual decline rate was significantly accelerated by 19.3% [95% confidence interval (CI) = 1.9% to 36.2%] for Trials 1–3 and 14.8% (4.4% to 24.9%) for List B performance, adjusting for multiple potential confounders. Long-term PM2.5 exposure was associated with increased Alzheimer’s disease pattern similarity scores, which accounted for 22.6% (95% CI: 1% to 68.9%) and 10.7% (95% CI: 1.0% to 30.3%) of the total adverse PM2.5 effects on Trials 1–3 and List B, respectively. The observed associations remained after excluding incident cases of dementia and stroke during the follow-up, or further adjusting for small-vessel ischaemic disease volumes. Our findings illustrate the continuum of PM2.5 neurotoxicity that contributes to early decline of immediate free recall/new learning at the preclinical stage, which is mediated by progressive atrophy of grey matter indicative of increased Alzheimer’s disease risk, independent of cerebrovascular damage."
deleted 7y ago
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VC999 7y ago

So you would think that men are imune to pollution.

alwaysanagenda 7y ago
I would think that a study on the effect of pollution on the brain should include men and women, because it's clearly unknown if it can affect women or men more strongly, or the same, or somehow different, depending on a myriad biological factors which differentiates between the sexes. I'm just pointing out that the data is absent.
khuey 7y ago
Even if men were immune poisoning only half the population still seems like a bad idea.

WhompingWindows 7y ago

Your quote is only from first half of the abstract... You haven't even quoted any statistics, where are you getting "statistically insignificant" from? The article itself shows that there is an association between AD and long-term PM2.5. See below for some actual statistical findings: "In multilevel structural equation models, PM2.5 was associated with greater declines in immediate recall and new learning, but no association was found with decline in delayed-recall or composite scores. For each interquartile increment (2.81 μg/m3) of PM2.5, the annual decline rate was significantly accelerated by 19.3% [95% confidence interval (CI) = 1.9% to 36.2%] for Trials 1–3 and 14.8% (4.4% to 24.9%) for List B performance, adjusting for multiple potential confounders. Long-term PM2.5 exposure was associated with increased Alzheimer’s disease pattern similarity scores, which accounted for 22.6% (95% CI: 1% to 68.9%) and 10.7% (95% CI: 1.0% to 30.3%) of the total adverse PM2.5 effects on Trials 1–3 and List B, respectively. The observed associations remained after excluding incident cases of dementia and stroke during the follow-up, or further adjusting for small-vessel ischaemic disease volumes. Our findings illustrate the continuum of PM2.5 neurotoxicity that contributes to early decline of immediate free recall/new learning at the preclinical stage, which is mediated by progressive atrophy of grey matter indicative of increased Alzheimer’s disease risk, independent of cerebrovascular damage."

deleted 7y ago

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