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Are 5-HT2A and 5-HT2C related to 5-HT2B at all? Don't psychedelics like LSD, DMT, and MDMA non-selectively target those receptors?
by leggomylibro 7y ago
Are 5-HT2A and 5-HT2C related to 5-HT2B at all? Don't psychedelics like LSD, DMT, and MDMA non-selectively target those receptors?
- heavyset_go 7y agoTraditional psychedelics are 5-HT2A agonists, while 5-HT2A antagonism or inverse agonism is associated with an anxiolytic and antidepressant effect. Certain psychedelics like psilocybin are 5-HT2C agonists, which is responsible for the anxiety, dysphoria and nausea that some people experience when they consume it. > Are 5-HT2A and 5-HT2C related to 5-HT2B at all? You'd really need to look at in vivo binding profiles when it comes to serotonergic drugs. Some drugs are selective for other receptor subtypes compared to 5-HT2B, others aren't. Almost all antidepressants are tested for 5-HT2B affinity because of the association with heart disease and birth defects, and because of the lawsuits that resulted from them.