The fact that PDF is immutable is a huge advantage. In Polar we have taken the perspective that immutability is an advantage and is going to be the basis for o

The fact that PDF is immutable is a huge advantage. In Polar we have taken the perspective that immutability is an advantage and is going to be the basis for our group collaboration around documents. We ended up building out annotations on top of PDF including text highlights and area highlights which can then be commented on: https://getpolarized.io/docs/annotation-sidebar.html https://getpolarized.io/docs/annotation-sidebar.html Some of our users keep asking for editable documentation and I think the main win here could just be using markdown which I'm thinking about adding. The biggest thing that's needed though, for scientific use, is latex. Fortunately, there are plenty of markdown implementations with latex support. PDF is amazingly good for printing documents but honestly 90% of the complex printing requirements aren't needed for regular use.