Exhaustion caused by chronic stress - general adaptation syndrome (formerly neurasthenia, now "other neurotic disorder") and depression share many features, but

Exhaustion caused by chronic stress - general adaptation syndrome (formerly neurasthenia, now "other neurotic disorder") and depression share many features, but the treatment is different. (Likewise PTSD.) Dysautonomia is related, maybe a feature that would be tractable pharmacologically. And probably harder as it's less understood. Nobody really knows how adaptation to stress works, much less how to fix the terminal exhaustion.