3 ms·
That could be one potential consequence but this publication just lays out the observation and clearly states this at the end - "It should be noted, however, th
by najarvg 7y ago
That could be one potential consequence but this publication just lays out the observation and clearly states this at the end - "It should be noted, however, that antigens recognized by clonally expanded TCRs are not known, and further work is required to characterize CD4 CTLs in supercentenarians." IOW, the actual characteristics of the T-cells in this sampled population is not known.
As frustrating as it sounds, more experiments are needed to say with certainty what is correlated, what is causal etc.
- jlokier 7y agoOoh, that observation that the antigens are not known sounds like a really promising field for analysis and discovery tools. Reverse engineering the antigens from the cells that have evolved to recognise them.
- wahern 7y agoA molecular biologist friend said "there is a super clever way to do it using phage screens", and pasted this link with some "limited info": https://en.wikipedia.org/wiki/PhIP-Seq https://en.wikipedia.org/wiki/PhIP-Seq