It is late and my head is fuzzy but from the research paper ( https://elifesciences.org/articles/46966 https://elifesciences.org/articles/46966) a few things ju

It is late and my head is fuzzy but from the research paper ( https://elifesciences.org/articles/46966 https://elifesciences.org/articles/46966) a few things jumped out at me - 'We found that our subtraction procedure, as well as other linear subtraction methods we tested, failed to produce accurate estimates of correlations between spines and the global reference signal'. & 'Inferred correlations between input (spines) and output (soma) did not reliably predict true correlations, even in simple and linear models of the relationship between activity and fluorescence signals in dendritic spines. This was also true for all linear subtraction methods we tested'.