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This sounds like a gross exaggeration: > Volunteers who took large doses of vitamins C and E before training failed to benefit from the workout. I find it har

by leshow 7y ago

This sounds like a gross exaggeration: > Volunteers who took large doses of vitamins C and E before training failed to benefit from the workout. I find it hard to believe that they didn't benefit at all from a workout because they took vitamin C or E. I'd like to see the methodology of this study if that's really the conclusion they came to.

refurb 7y ago
Here is the study if you want to dig into it![1] We know exercise improve insulin resistance and glucose uptake, so that's the benefit of exercise they measured. It's actually not that surprising. Vitamin C and E have anti-oxidant properties. Reactive oxygen species (ROS) are generated during metabolism. Generally we think of them as being bad since they can damage molecules in the body, but it appears that ROS are actually a signal to the body that causes it to improve cardiovascular fitness. Take too much vitamin C and E and you're blocking that signal. Derek Lowe has a nice blog post on it.[2] It's a good lesson in Chesterson's Fence. Before you tear down the fence (ROS), you may want to double check why it's there in the first place. [1]https://www.pnas.org/content/early/2009/05/11/0903485106.short?rss=1 https://www.pnas.org/content/early/2009/05/11/0903485106.sho... [2]https://blogs.sciencemag.org/pipeline/archives/2009/05/13/exercise_and_vitamins_now_wait_a_minute_ https://blogs.sciencemag.org/pipeline/archives/2009/05/13/ex...
- leshow 7y ago
  Thanks for the link. IMO that's a pretty narrow definition of what constitutes "benefit". You could say that about what they call a workout too I guess.
LinuxBender 7y ago
They should also be careful with E. Most supplements only have α-Tocopherol and not gamma. The imbalance increases risk of prostate cancer in males. Some studies found that increasing selenium offset the risk, but there is a point of diminishing returns where selenium becomes toxic.

by leshow 7y ago

refurb 7y ago

Here is the study if you want to dig into it![1] We know exercise improve insulin resistance and glucose uptake, so that's the benefit of exercise they measured. It's actually not that surprising. Vitamin C and E have anti-oxidant properties. Reactive oxygen species (ROS) are generated during metabolism. Generally we think of them as being bad since they can damage molecules in the body, but it appears that ROS are actually a signal to the body that causes it to improve cardiovascular fitness. Take too much vitamin C and E and you're blocking that signal. Derek Lowe has a nice blog post on it.[2] It's a good lesson in Chesterson's Fence. Before you tear down the fence (ROS), you may want to double check why it's there in the first place. [1]https://www.pnas.org/content/early/2009/05/11/0903485106.short?rss=1 https://www.pnas.org/content/early/2009/05/11/0903485106.sho... [2]https://blogs.sciencemag.org/pipeline/archives/2009/05/13/exercise_and_vitamins_now_wait_a_minute_ https://blogs.sciencemag.org/pipeline/archives/2009/05/13/ex...

leshow 7y ago
Thanks for the link. IMO that's a pretty narrow definition of what constitutes "benefit". You could say that about what they call a workout too I guess.

LinuxBender 7y ago

They should also be careful with E. Most supplements only have α-Tocopherol and not gamma. The imbalance increases risk of prostate cancer in males. Some studies found that increasing selenium offset the risk, but there is a point of diminishing returns where selenium becomes toxic.