3 ms·
You're welcome! This stuff is way outside my area of expertise, but I'm obviously curious what the heck is going on. Glad to see this discussion here on HN.
by heymijo 7y ago
You're welcome! This stuff is way outside my area of expertise, but I'm obviously curious what the heck is going on. Glad to see this discussion here on HN.
- refurb 7y agoThanks for posting the podcast link. As I mentioned earlier, testing pharmaceuticals is not easy. Usually you need to develop a specific method for each drug and then validate it. It’s very easy to actually introduce an impurity (or the appearance of an impurity) with the wrong process. Ranitidine (Zantac) is even more challenging when it comes to NMDA. Most drugs have that impurity from the manufacturing process. Solvents and chemicals react to produce traces of it. Ranitidine has the building blocks of NMDA in the molecule itself. So decomposition of ranitidine will produce NMDA. You could start with 100% pure ranitidine and if you test it wrong, you’ll produce NMDA and be convinced it was in the original material when it wasn’t.
- heymijo 7y agoAppreciate you breaking that down! Really illuminates how complex and challenging chemistry and biology are.
- deleted 7y ago[deleted]