> What happens when a new substance hits town? I don't mean to detract from the point you were trying to make, but a lot of the novel psychoactive substances t

> What happens when a new substance hits town? I don't mean to detract from the point you were trying to make, but a lot of the novel psychoactive substances that have appeared in recent times (e.g. synthetic cannabinoids such as spice) only ever came to be because of current drug regulations - they were created because in many countries individual drugs are outlawed, so if you create a new one, it will be legal to sell it for a time. The "traditional" drugs are more than enough for most psychonauts - why risk some novel substance with an unknown safety profile if you could legally and safely obtain high-quality cannabis, MDMA, cocaine etc?