I have a few hundred Citrix VDI users, many of whom need to occasionally download a WebExLongHash123.exe file. Is there any way to use Sandboxie to auto-run the

I have a few hundred Citrix VDI users, many of whom need to occasionally download a WebExLongHash123.exe file. Is there any way to use Sandboxie to auto-run these downloaded files in the sandbox so that if they are actual malware, it won't affect the rest of the system?