Most mutations are probably large scale chromosomal missegregation, etc where huge chunks get moved around or duplicated/deleted rather than just replacing/remo

Most mutations are probably large scale chromosomal missegregation, etc where huge chunks get moved around or duplicated/deleted rather than just replacing/removing/adding a single nucleotide. From what I have read something like that happens about once every 10 divisions per cell line. So I think that could be more difficult than you expect.