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> That is like artificial selection on steroids No, it's not, because you are selecting on genotype rather than phenotype. Embryo selection only works when th
by jakobegger 7y ago
> That is like artificial selection on steroids
No, it's not, because you are selecting on genotype rather than phenotype.
Embryo selection only works when there is a simple connection between genotype and phenotype (eg. what type of earlobes do you prefer). For complex traits like "intelligence", selecting based on genotype is not going to work. To much noise, too little signal.
- sanxiyn 7y agoNote that we are already doing genotype selection on dairy cattles using "net merit", a proxy for lifetime profit, and succeeding. That's pretty complex too.
- haihaibye 7y agoPolygenic risk scores are the distillation of the signal, achieved by enormous sample sizes. They work. Fisher showed in 1918 you can perform selection even if there were an infinite number of loci involved, see https://en.m.wikipedia.org/wiki/Infinitesimal_model https://en.m.wikipedia.org/wiki/Infinitesimal_model