3 ms·
The article I linked put it way better than I did, so I'll just quote that for clarification: > One of the key problems is that polygenic scores are the sum of
by pjscott 7y ago
The article I linked put it way better than I did, so I'll just quote that for clarification:
> One of the key problems is that polygenic scores are the sum of many individual small genes’ effects and form a normal distribution, which is tightly distributed around a mean; the further into the tail one goes, the larger a sample it requires to realize a gain—to put it another way, if you have 10 samples, it’s easy (a 1 in 10 probability) that your next random sample will be the largest sample yet, but if you have 100 samples, now the probability of an improvement is the much harder 1 in 100, and if you have 1000, it’s only 1 in 1000, and worse, if you luck out and there’s an improvement, the improvement is ever tinier.