Depends on your use case and operating systems. Are either/both of the monitors high DPI? Do you want thinks to look 'sharper' or do you want more screen real e

Depends on your use case and operating systems. Are either/both of the monitors high DPI? Do you want thinks to look 'sharper' or do you want more screen real estate. It also depends on which operating system you are using. Scaling on Linux is pretty terrible so I wanted a monitor that had ~100dpi so that no special scaling would be required. I also wanted the screen real estate of 4 ~22" monitors, so a 43" 4k monitor was perfect for my use case.