I never realised that the APOE variant bound heparin sulfate (HS). HS is actually a cool molecule (glycan) from the perspective of its ability to encode informa

I never realised that the APOE variant bound heparin sulfate (HS). HS is actually a cool molecule (glycan) from the perspective of its ability to encode information in its pattern of sulfation. The signals can be mixed and the precise binding partners for a single molecule can be programmed in. How this is all regulated, and the extent this happens in nature is still being worked out.