I've found one of the best compromises is using setting uBlock Origin to advanced user mode, globally block 3rd party frames, and enabling a few extra filters t

I've found one of the best compromises is using setting uBlock Origin to advanced user mode, globally block 3rd party frames, and enabling a few extra filters that I don't know off hand. Most sites will still mostly work, and the few that don't usually just need a CDN to be enabled (you can do this per-site).