There are no real differences beyond those arising from differences in aperture and focal length. For example, here are two very similar shots, one shot on a DX

There are no real differences beyond those arising from differences in aperture and focal length. For example, here are two very similar shots, one shot on a DX format DSLR and the other shot on 4x5 film: https://drive.google.com/open?id=0B4v6yNyRkl5uUThuRm9tVWhGNUE https://drive.google.com/open?id=0B4v6yNyRkl5uUThuRm9tVWhGNU... https://drive.google.com/open?id=0B4v6yNyRkl5ua1BlMzNHVlRUUHc https://drive.google.com/open?id=0B4v6yNyRkl5ua1BlMzNHVlRUUH... The one exception would be movements: most 4x5 cameras can do tilt and shift, whereas tilt/shift lenses for DSLRs are very expensive and specialist.