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DART is described in the article as a "A Molecular GPS to Target Neurons", one of the points mentioned in selectively treating the neurons for a Parkinson’s mou
by rajnathani 7y ago
DART is described in the article as a "A Molecular GPS to Target Neurons", one of the points mentioned in selectively treating the neurons for a Parkinson’s mouse model is:
> Rather than treat the disorder by increasing dopamine (the standard treatment), they used DART to stop the D2 type of neuron from compensating by delivering a glutamate antagonist specifically to these cells in the striatum. The animal’s movement dramaticallyimproved. Remarkably, this improvement was only seen when the drug was targeted exclusively to D2 cells; delivering the drug to both D1 and D2 cells had no benefit.