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Zooming in on Neuronal Behavior, using DART to treat Parkinson's Disease
- rajnathani 7y agoDART is described in the article as a "A Molecular GPS to Target Neurons", one of the points mentioned in selectively treating the neurons for a Parkinson’s mouse model is: > Rather than treat the disorder by increasing dopamine (the standard treatment), they used DART to stop the D2 type of neuron from compensating by delivering a glutamate antagonist specifically to these cells in the striatum. The animal’s movement dramaticallyimproved. Remarkably, this improvement was only seen when the drug was targeted exclusively to D2 cells; delivering the drug to both D1 and D2 cells had no benefit.