Oh boy, that rant. Doubtless the most far reaching and influential thing I have ever written. It gets assigned in bioinformatics classes around the world, which

Oh boy, that rant. Doubtless the most far reaching and influential thing I have ever written. It gets assigned in bioinformatics classes around the world, which puzzles me in the extreme, and I get emails every couple of months from new readers of it asking my position. My usual response these days is that if it's raising red flags for them, they should explore what troubles them until they have satisfied themselves rather than taking the word of some random guy on the Internet. From here inside my head, I think my criticisms are still accurate, nor have I seen any actual refutation of them. Lots of ad hominems. Many people not understanding that terms like "computationally difficult" are precise terms of art, and have nothing to do with intellectual or conceptual difficulty. With age and humility and, more importantly, absence, my attitude is probably better described as "meh."