The delivery method is generally the missing piece. For the first of the reports mentioned here the authors used bacterial conjugation [1] as the delivery met

The delivery method is generally the missing piece. For the first of the reports mentioned here the authors used bacterial conjugation [1] as the delivery method. They note that: "In culture conditions that enhance cell-to-cell contact, conjugation rates approach 100% with the cis-acting plasmid." So, I guess what is less clear is if this would me the case in a real bacterial infection. And would this generalize to a broad spectrum of pathogenic bacteria? The delivery mechanism in the second, anti-viral, paper is less clear to me. Perhaps someone else can comment. In general, I still like the idea of using bacteriophages. But finding broad spectrum bacteriophages seems problematic. Using DNA sequencing as a diagnostic to target therapies seems like in interesting idea (once DNA sequencing becomes cheap enough and easily available). [1] https://en.wikipedia.org/wiki/Bacterial_conjugation https://en.wikipedia.org/wiki/Bacterial_conjugation