I think their lesion approach is a little awkward and probably doesn't map that well between the fields. Removing a transistor, IMHO, is more akin to removing

I think their lesion approach is a little awkward and probably doesn't map that well between the fields. Removing a transistor, IMHO, is more akin to removing an eye or some other body part. Yeah, it allows one to determine if that transitor was important, but its impact on behavior is due to damaged hardware. Plus, the software probably can't be written to compensate for missing transistors. Instead of removing transistors from the CPU to determine if it was important to the "behavior" of the game, I think it would be more analogous to delete portions of memory and see if that alters game behavior. Even then, I think it's much more likely to cause a crash if done without some a priori information.