There's evidence that classical (5-HT2a agonist) psychedelics can have a permanent impact on a person's openness score (as part of the Big 5): https://www.psych

There's evidence that classical (5-HT2a agonist) psychedelics can have a permanent impact on a person's openness score (as part of the Big 5): https://www.psychologytoday.com/au/blog/unique-everybody-else/201604/psychedelic-drugs-and-the-nature-personality-change https://www.psychologytoday.com/au/blog/unique-everybody-els...