I had a girlfriend get pretty severely depressed upon starting birth control (and it cleared up shortly after going off) and traveled with a girl in Bolivia who

I had a girlfriend get pretty severely depressed upon starting birth control (and it cleared up shortly after going off) and traveled with a girl in Bolivia who had to give herself shots a few times a day because she had gotten deep vein thrombosis on her flight, susceptibility to which is apparently a side effect of her birth control. It really is insane how much it affects the user's health.