If by novel you also imply compatible, then sure. The moment you create a machine that's incompatible with the conventions adopted by the most popular compilers

If by novel you also imply compatible, then sure. The moment you create a machine that's incompatible with the conventions adopted by the most popular compilers and architectures, you break a ton of software built upon those conventions, and sink your hardware in the market because it's a portability nightmare. Specs don't matter beyond the conventions they inspire.