Set and setting play a huge part. I've gone pretty hard, dosage wise, and still felt like the same ol' me after. I've also had a pretty life-changing ego deat

Set and setting play a huge part. I've gone pretty hard, dosage wise, and still felt like the same ol' me after. I've also had a pretty life-changing ego death experience that lasted a few days after a pretty low dose. Several fellow psychonauts agreed that a certain friend could reap great benefits from it but after he tried it he was like, "meh". Over the following four years we did it together six times and on the last one he was like "woah, ok, now I respect this chemical". Similar dosage each time. Different trips take you different places.