4 ms·

Did you even read the paper in your second link? Nothing in that review suggests "_a lot_ of redundant evidence backing up effects" on the microbiome. Excerpt

by huge87 7y ago

Did you even read the paper in your second link? Nothing in that review suggests "_a lot_ of redundant evidence backing up effects" on the microbiome. Excerpt from the review: "To our knowledge, there are no data on the potential influences of aspartame on the human gut microbiome. It is hard to understand how aspartame influences the gut microbiota because this NNS is rapidly hydrolyzed in the small intestine. In fact, even with the ingestion of very high doses of aspartame (>200 mg/kg), no aspartame is found in the blood because of its rapid breakdown (29). Upon ingestion, aspartame breaks down into residual components, including aspartic acid, phenylalanine, and methanol and their components, which are readily absorbed so that they do not reach the large bowel (30)"

post_below 7y ago
I did read it, you maybe didn't, if you had you couldn't say "nothing in that review suggests..." with a straight face. There's quite a lot of evidence cited in that review. Also in the paragraph directly before the one you quoted you must have skipped over this: "Aspartame consumption increased the fasting glucose concentrations in both the standard feed pellet diet and high-fat groups independent of body composition. A metabolomics analysis showed that aspartame was rapidly metabolized and related to SCFA production, especially propionate production. Changes in the microbial composition were observed in animals that received aspartame; the total bacteria and abundance of Enterobacteriaceae and Clostridium leptum increased." If you don't find that convincing, here's the first Google result for "aspartame microbiome": https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615743/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615743/ By your response I'm not sure if maybe you think I'm making this stuff up? If you're really interested you won't have to spend much time searching to find a wealth of info.
- masonic 7y ago
  Those comments are specific to aspartame, which is a tiny minority of AS use nowadays.
- 21240fl00rbot 7y ago
  Ok that's an animal study that suggests some changes in microbiome, still need to show its applicable to humans and that the changes are meaningful to health in anyway. The second paper doesn't make any definitive claims on health or humans either. There are reviews of multiple blinded, randomized controlled trials showing no adverse health outcomes. Are any such meta-analyses that show there are? Animal trials at extremely and dosages coupled with some human trials suggesting (without controlling for confounding factors) possible changes in gut microbiome without demonstrating any meaningful health outcomes is significantly less convincing.

by huge87 7y ago

post_below 7y ago

I did read it, you maybe didn't, if you had you couldn't say "nothing in that review suggests..." with a straight face. There's quite a lot of evidence cited in that review. Also in the paragraph directly before the one you quoted you must have skipped over this: "Aspartame consumption increased the fasting glucose concentrations in both the standard feed pellet diet and high-fat groups independent of body composition. A metabolomics analysis showed that aspartame was rapidly metabolized and related to SCFA production, especially propionate production. Changes in the microbial composition were observed in animals that received aspartame; the total bacteria and abundance of Enterobacteriaceae and Clostridium leptum increased." If you don't find that convincing, here's the first Google result for "aspartame microbiome": https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615743/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615743/ By your response I'm not sure if maybe you think I'm making this stuff up? If you're really interested you won't have to spend much time searching to find a wealth of info.

masonic 7y ago
Those comments are specific to aspartame, which is a tiny minority of AS use nowadays.
21240fl00rbot 7y ago
Ok that's an animal study that suggests some changes in microbiome, still need to show its applicable to humans and that the changes are meaningful to health in anyway. The second paper doesn't make any definitive claims on health or humans either. There are reviews of multiple blinded, randomized controlled trials showing no adverse health outcomes. Are any such meta-analyses that show there are? Animal trials at extremely and dosages coupled with some human trials suggesting (without controlling for confounding factors) possible changes in gut microbiome without demonstrating any meaningful health outcomes is significantly less convincing.