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I would also add that journals like Nature or Science are aiming to publish high quality, high impact work in a manner that is highly specific (i.e they can be

I would also add that journals like Nature or Science are aiming to publish high quality, high impact work in a manner that is highly specific (i.e they can be confident such work is high quality and high impact) and hopefully communicable to a somewhat broad audience. Ground breaking ideas out of left field may need some more time to mature before such journals would be comfortable publishing such work.

Beldin 7y ago
In other words, journals try to predict the future (impact) while the Nobel committee looks at the past (impact). More specifically, journals like significant advances in known fields (eg, doubling the efficiency of solar panels), while the Nobel committee likes research that opens up a new field (eg, looking for exo planets). In that light, maybe it's more surprising to see a Nobel-awarded piece of research was published in Nature than to see it was rejected by Nature.