I suspect that Michel Mayor is right about exoplanets but we might be able to colonize the moon or Mars. I've wondered how evolution will affect humans that are

I suspect that Michel Mayor is right about exoplanets but we might be able to colonize the moon or Mars. I've wondered how evolution will affect humans that are born in space colonies. I would think that over a few generations it would be impossible for a space-born human to return to earth without special equipment. At the very least the difference in gravity would change how much weight our bones can support. I would also think that the increase in radiation would cause many more mutations. So even if we are able to colonize nearby space humans in space colonies would evolve into different human species over time. In some sense, it means that humans, as we are now, could never leave earth and colonize space.