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What's the probability that the sequencing sample was contaminated and that the sequence result doesn't represent the animal in question? Has that been ruled ou
by justinjlynn 7y ago
What's the probability that the sequencing sample was contaminated and that the sequence result doesn't represent the animal in question? Has that been ruled out?
Obviously such integration errors occur in reality. Though, in therapy I'd expect the rates to be quite low. It'd be interesting to find out how often it happens in these applications.
- aae42 7y agosuperheros?
- ben_w 7y agoWell, the Milkybar Kid is one of the few superheroes whose origin story has not been done to death in the endless reboots that afflicts the genre, so that could work as a good story…
- mbreese 7y agoIntegration errors aren’t the main concern with treating patients - it’s the off target effects. In other words, changes to genes you didn’t expect. You don’t want to fix one problem, only to cause something else. IIRC, the reason why the integration errors were such a big deal is because they made it to the germline of the animal and could be transferred to offspring. This would have been extensively validated given the amount of press and regulatory pressure.